Value of radiation therapy in addition to surgery for cancer of the head and neck
| Autor: | Luu Tran, Hans Kuisk, William L. Grist, Ahmad Sadeghi, John R. Mclaren |
|---|---|
| Rok vydání: | 1986 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment 03 medical and health sciences 0302 clinical medicine medicine Carcinoma Combined Modality Therapy Humans 030223 otorhinolaryngology Postoperative Care Clinical Trials as Topic Hypopharyngeal Neoplasms business.industry Cancer Neck dissection Pharyngeal Neoplasms medicine.disease Primary tumor Surgery Radiation therapy stomatognathic diseases Oropharyngeal Neoplasms Otorhinolaryngology 030220 oncology & carcinogenesis Lymphatic Metastasis Carcinoma Squamous Cell Neck Dissection Mouth Neoplasms Lymph Positive Surgical Margin Neoplasm Recurrence Local business |
| Zdroj: | Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery. 94(5) |
| ISSN: | 0194-5998 |
| Popis: | This historically controlled study evaluates radiation therapy in 119 patients--with squamous cell carcinomas of the head and neck--who underwent surgery alone (SA) or surgery plus radiation (S + R). The primary tumor control and nodal control, in patients with negative surgical margins who had surgery alone (SA), were 63% in the oral cavity, 60% in the oropharynx, and 67% in the hypopharynx. The same rates for S + R group and negative surgical margins were 100%, 73%, and 100%. Combining the patients with negative and positive surgical margins, control of the tumor and nodal control were the same in the oral cavity for both treatment groups (41% for SA and 44% for S + R) and increased with the addition of radiation in the oropharynx (30% for SA to 65% for S + R) and hypopharynx (33% for SA to 86% for S + R), in spite of higher percentages of T3 and T4 tumor and positive lymph nodes in the S + R group. The lower control rate in patients who had surgery alone could be due (in part) to inadequate surgery at the primary site (42% local excision) and lack of neck dissection (35% for SA vs. 77% for S + R). Postoperative radiation therapy to the primary site and neck is shown to effectively reduce local recurrence in patients with oral cavity and oropharynx cancer, regardless of surgical margins. |
| Databáze: | OpenAIRE |
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