Magnetic Silica-Coated Iron Oxide Nanochains as Photothermal Agents, Disrupting the Extracellular Matrix, and Eradicating Cancer Cells
| Autor: | Anouchka Plan Sangnier, Muriel Golzio, Isabelle Fourquaux, Elena Griseti, Sebastjan Nemec, Marie-Pierre Rols, Slavko Kralj, Jelena Kolosnjaj-Tabi, Claire Wilhelm, Elisabeth Bellard |
|---|---|
| Přispěvatelé: | Institut de pharmacologie et de biologie structurale (IPBS), Centre National de la Recherche Scientifique (CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, Jozef Stefan Institute [Ljubljana] (IJS), University of Ljubljana, Matière et Systèmes Complexes (MSC (UMR_7057)), Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Centre de Microscopie Électronique Appliquée à la Biologie (CMEAB), Hôpital de Rangueil, CHU Toulouse [Toulouse]-CHU Toulouse [Toulouse]-Toulouse Réseau Imagerie-Genotoul ( TRI-Genotoul), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE) |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
collagen
Cancer Research Nanoparticle [SDV.CAN]Life Sciences [q-bio]/Cancer 02 engineering and technology [CHIM.THER]Chemical Sciences/Medicinal Chemistry Matrix (biology) 010402 general chemistry magnetic silica-coated iron oxide nanochains 01 natural sciences Article Extracellular matrix 3D cell culture Cytotoxic T cell cancer Tumor microenvironment Chemistry cellular microenvironment Photothermal therapy 021001 nanoscience & nanotechnology hyperthermia photothermal treatment 0104 chemical sciences Oncology Cancer cell Biophysics [SDV.SP.PHARMA]Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology nanoparticles 0210 nano-technology |
| Zdroj: | Cancers Volume 11 Issue 12 Cancers, MDPI, 2019, 11 (12), pp.2040. ⟨10.3390/cancers11122040⟩ |
| ISSN: | 2072-6694 |
| DOI: | 10.3390/cancers11122040 |
| Popis: | International audience; Cancerous cells and the tumor microenvironment are among key elements involved in cancer development, progression, and resistance to treatment. In order to tackle the cells and the extracellular matrix, we herein propose the use of a class of silica-coated iron oxide nanochains, which have superior magnetic responsiveness and can act as efficient photothermal agents. When internalized by different cancer cell lines and normal (non-cancerous) cells, the nanochains are not toxic, as assessed on 2D and 3D cell culture models. Yet, upon irradiation with near infrared light, the nanochains become efficient cytotoxic photothermal agents. Besides, not only do they generate hyperthermia, which effectively eradicates tumor cells in vitro, but they also locally melt the collagen matrix, as we evidence in real-time, using engineered cell sheets with self-secreted extracellular matrix. By simultaneously acting as physical (magnetic and photothermal) effectors and chemical delivery systems, the nanochain-based platforms offer original multimodal possibilities for prospective cancer treatment, affecting both the cells and the extracellular matrix. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|