p63 and E-cadherin Expression in Canine Oral Squamous Cell Carcinoma
| Autor: | Maria C. Peleteiro, Maria M. R. E. Niza, Hugo Pissarra, Mauro Bragança, Lisa A Mestrinho, Pedro Faísca |
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| Rok vydání: | 2014 |
| Předmět: |
Male
Cytoplasm Pathology medicine.medical_specialty Proliferative index Cell Dogs Biomarkers Tumor Animals Medicine Mouth neoplasm General Veterinary biology business.industry Cadherin Tumor Suppressor Proteins Cadherins Immunohistochemistry Staining Proliferating cell nuclear antigen stomatognathic diseases medicine.anatomical_structure Lymphatic Metastasis Carcinoma Squamous Cell biology.protein Canine Oral Squamous Cell Carcinoma Female Mouth Neoplasms sense organs business |
| Zdroj: | Veterinary Pathology. 52:614-620 |
| ISSN: | 1544-2217 0300-9858 |
| Popis: | The expression of p63 and E-cadherin was studied in 22 oral squamous cell carcinomas in the dog according to immunohistochemical techniques. The association between these markers and clinicopathologic parameters was assessed. All tumor cells studied showed enhanced p63 expression. Regarding E-cadherin expression, 17 of 22 cases (77.3%) showed decreased immunoreactivity, and in 13 of 22 cases (59.1%), its expression was cytoplasmic. Neither p63 nor E-cadherin expression patterns were associated with tumor size, bone invasion, or lymph node metastasis. p63 score was related to proliferating cell nuclear antigen proliferative index ( P = .020). A statistically significant correlation between the expression patterns of these 2 markers was noted ( P = .026). Furthermore, they were related with tumor grade. An atypical p63 labeling and a cytoplasmic E-cadherin staining were statistically related with a higher tumor grade ( P = .022 and P = .017, respectively). These findings suggest that changes in p63 and E-cadherin expression are frequent events in oral squamous cell carcinoma in dogs. |
| Databáze: | OpenAIRE |
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