An immunogenomic phenotype predicting behavioral treatment response: Toward precision psychiatry for mothers and children with trauma exposure
| Autor: | Steve W. Cole, Alyssa Baccarella, Luisa M. Rivera, Alicia F. Lieberman, Owen M. Wolkowitz, Nicole R. Bush, Kirstin Aschbacher, Melissa J. Hagan |
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| Rok vydání: | 2021 |
| Předmět: |
Proteomics
Psychiatry Treatment response medicine.medical_specialty Endocrine and Autonomic Systems business.industry Immunology Behavioral treatment Mothers Maternal blood medicine.disease Phenotype Stress Disorders Post-Traumatic Behavioral Neuroscience Chronic disease Internal medicine Child Preschool Medicine Antidepressant Humans Female business Depression (differential diagnoses) Psychological trauma |
| Zdroj: | Brain, behavior, and immunity. 99 |
| ISSN: | 1090-2139 |
| Popis: | Inflammatory pathways predict antidepressant treatment non-response among individuals with major depression; yet, this phenomenon may have broader transdiagnostic and transtherapeutic relevance. Among trauma-exposed mothers (Mage = 32 years) and their young children (Mage = 4 years), we tested whether genomic and proteomic biomarkers of pro-inflammatory imbalance prospectively predicted treatment response (PTSD and depression) to an empirically-supported behavioral treatment. Forty-three mother-child dyads without chronic disease completed Child Parent Psychotherapy (CPP) for roughly 9 months. Maternal blood was drawn pre-treatment, CD14 + monocytes isolated, gene expression derived from RNA sequencing (n = 34; Illumina HiSeq 4000;TruSeqcDNA library), and serum assayed (n = 43) for C-Reactive Protein (CRP) and interleukin-1s (IL-1s). Symptoms of PTSD and depression decreased significantly from pre- to post-treatment for both mothers and children (all p's |
| Databáze: | OpenAIRE |
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