Impact of pre-radiation therapy quality of life in lung cancer survival: a prospective, intention-to-treat, multicenter study
| Autor: | J.M. Praena Fernández, J.L. Lopez Guerra, E Rivin Del Campo, M.J. Ortiz Gordillo, D. Herrero Rivera, B.D. Delgado Leon, G P Silva Vega, Jon Cacicedo, J.M. Nieto-Guerrero Gómez |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male 0301 basic medicine Quality of life Cancer Research medicine.medical_specialty Lung Neoplasms Health Status medicine.medical_treatment Lower risk 03 medical and health sciences 0302 clinical medicine Carcinoma Non-Small-Cell Lung Surveys and Questionnaires Internal medicine medicine Risk of mortality Humans Prospective Studies Lung cancer Aged Outcome Aged 80 and over Intention-to-treat analysis business.industry General Medicine Middle Aged Prognosis medicine.disease Dysphagia Intention to Treat Analysis Survival Rate Radiation therapy 030104 developmental biology Oncology 030220 oncology & carcinogenesis Cohort Female medicine.symptom business |
| Zdroj: | Digital.CSIC. Repositorio Institucional del CSIC instname |
| Popis: | [Purpose]: Lung cancer (LC) has a significant impact on patients’ health-related quality of life (HRQoL). We investigate the correlations between pre-radiation therapy HRQoL and survival. [Materials and methods]: A prospective, intention-to-treat, multicentre study of 437 patients with LC recruited at the radiation oncology departments of three different institutions was conducted between 2012 and 2016. QoL was assessed using the EORTC-QLQ-C30 (v3.0) and EORTC-QLQ-LC13 questionnaires. Global health status (GHS), physical (PF), role functioning (RF), emotional (EF), cognitive (CF), and social functioning (SF) as well as symptoms scores were evaluated in univariate and multivariate analyses. [Results]: The cohort consisted of 376 men (86%) and 61 women, with a median age of 66 years (range 31–88). Histology was: 72% (n = 315) non-small cell lung cancer and 28% small cell lung cancer. The most common stage was III (80%) and the median follow-up for alive patients was 30 months (range 7–76). Multivariate analysis showed that RF was associated with a lower risk of mortality (HR: 0.693; p = 0.008) and recurrence (HR: 0.737; p = 0.040). Additionally, lower scores on EF and PF were associated with higher mortality (HR: 0.696; p = 0.003 and HR: 0.765; p = 0.044, respectively). Appetite loss, constipation, and dysphagia were associated with a higher risk of mortality (HR: 1.985; p |
| Databáze: | OpenAIRE |
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