SUR1 Receptor Interaction with Hesperidin and Linarin Predicts Possible Mechanisms of Action of Valeriana officinalis in Parkinson
| Autor: | Bruno Silva Andrade, Lisandro Diego Giraldez-Alvarez, Aristóteles Góes Neto, George E. Barreto, Marco Avila-Rodriguez, Francisco Capani, Gesivaldo Santos, Eduardo Galembeck |
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| Přispěvatelé: | Univ Estadual Sudoeste Bahia, Pontificia Univ Javeriana, UBA CONICET, Universidade Estadual Paulista (Unesp), Univ Fed Estadual Feira Santana, Univ Autonoma Chile, Univ Cient Sur |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Aging Valeriana officinalis CIENCIAS MÉDICAS Y DE LA SALUD Cognitive Neuroscience Inmunología Substantia nigra Biology Pharmacology medicine.disease_cause Neuroprotection 03 medical and health sciences chemistry.chemical_compound Hesperidin 0302 clinical medicine IN SILICO medicine Original Research Rotenone purl.org/becyt/ford/3.1 [https] GABAA Valerenic acid Parkinson disease Medicina Básica 030104 developmental biology chemistry SUR1 Apigenin purl.org/becyt/ford/3 [https] VALERINA LINARIN neuroprotection PARKINSON 030217 neurology & neurosurgery Oxidative stress Neuroscience |
| Zdroj: | Web of Science Repositório Institucional da UNESP Universidade Estadual Paulista (UNESP) instacron:UNESP CONICET Digital (CONICET) Consejo Nacional de Investigaciones Científicas y Técnicas instacron:CONICET Frontiers in Aging Neuroscience |
| Popis: | Made available in DSpace on 2018-11-26T15:29:25Z (GMT). No. of bitstreams: 0 Previous issue date: 2016-05-02 Universidade Estadual do Sudoeste da Bahia Pontificia Universidad Javeriana Jovenes Investigadores (Colciencias) Parkinson's disease (PD) is one of the most common neurodegenerative disorders. A theoretical approach of our previous experiments reporting the cytoprotective effects of the Valeriana officinalis compounds extract for PD is suggested. In addiction to considering the PD as a result of mitochondrial metabolic imbalance and oxidative stress, such as in our previous in vitro model of rotenone, in the present manuscript we added a genomic approach to evaluate the possible underlying mechanisms of the effect of the plant extract. Microarray of substantia nigra (SN) genome obtained from Allen Brain Institute was analyzed using gene set enrichment analysis to build a network of hub genes implicated in PD. Proteins transcribed from hub genes and their ligands selected by search ensemble approach algorithm were subjected to molecular docking studies, as well as 20 ns Molecular Dynamics (MD) using a Molecular Mechanic Poison/Boltzman Surface Area (MMPBSA) protocol. Our results bring a new approach to Valeriana officinalis extract, and suggest that hesperidin, and probably linarin are able to relieve effects of oxidative stress during ATP depletion due to its ability to binding SUR1. In addition, the key role of valerenic acid and apigenin is possibly related to prevent cortical hyperexcitation by inducing neuronal cells from SN to release GABA on brain stem. Thus, under hyperexcitability, oxidative stress, asphyxia and/or ATP depletion, Valeriana officinalis may trigger different mechanisms to provide neuronal cell protection. Univ Estadual Sudoeste Bahia, Dept Ciencias Biol, Jequie, Brazil Univ Estadual Sudoeste Bahia, Dept Quim & Exatas, PNPD CAPES, Jequie, Brazil Pontificia Univ Javeriana, Fac Ciencias, Dept Nutr & Bioquim, Bogota, DC, Colombia UBA CONICET, Inst Invest Cardiol Prof Dr Alberto C Taquini INI, Buenos Aires, DF, Argentina Univ Estadual Paulista, Inst Biol, Dept Bioquim, Campinas, SP, Brazil Univ Fed Estadual Feira Santana, Dept Ciencias Biol, Feira De Santana, Brazil Univ Autonoma Chile, Inst Ciencias Biomed, Santiago, Chile Univ Cient Sur, Lima, Peru Univ Estadual Paulista, Inst Biol, Dept Bioquim, Campinas, SP, Brazil Pontificia Universidad Javeriana: 5575 Pontificia Universidad Javeriana: 5024 Jovenes Investigadores (Colciencias): 6027 |
| Databáze: | OpenAIRE |
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