Effects of peritoneal lavage with lidocaine on survival of rats with fecal peritonitis
| Autor: | Thiago Antunes Ferrari, Thiago Caetano V. de Azevedo, Alcino Lázaro da Silva, Danilo Nagib Salomão Paulo, João Florêncio de Abreu Baptista, Marcos Célio Brocco |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Lidocaine
Fecal peritonitis medicine.medical_treatment Anti-Inflammatory Agents Drug Evaluation Preclinical Sepse Peritonitis Abdominal cavity Sodium Chloride Anestesia Sepsis Feces Random Allocation Laparotomy medicine Animals Peritonite Peritoneal Lavage Anesthesia Anesthetics Local Rats Wistar Saline Anesthesia/methods business.industry medicine.disease Rats Disease Models Animal medicine.anatomical_structure Surgery business medicine.drug |
| Zdroj: | Acta Cirurgica Brasileira, Volume: 23, Issue: 1, Pages: 42-47, Published: FEB 2008 Acta Cirúrgica Brasileira v.23 n.1 2008 Acta Cirúrgica Brasileira Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) instacron:SBDPC |
| ISSN: | 0102-8650 |
| Popis: | PURPOSE: To study the effects of peritoneal lavage with a 2% lidocaine solution, on the survival of the rats submitted to peritonitis caused by their own feces. METHODS: Forty-eight Wistar rats, weighting between 300g and 330g (mean, 311,45 ±9,67g), were submitted to laparotomy 6 hours following induction of fecal peritonitis. Animals were randomly divided into four groups of 12 each as follows: 1- Control, no therapy; 2- Drying of the abdominal cavity; 3- Peritoneal lavage with saline and drying; 4- Peritoneal lavage with a 2% lidocaine solution and drying. Animals that died were submitted to necropsy and the time of their death recorded; survivors were killed on the post-operation 11th day and necropsied. RESULTS: Death occurred within 52 h in all animals of group 1; within 126 h in 100% of those of group 2; within 50 h in 50% of those of group 3. All animals of group 4 survived. Survival on the 11 th day was higher in groups 3 and 4 than in groups 1 and 2 (p |
| Databáze: | OpenAIRE |
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