Impaired bacterial killing in early obstructive jaundice
| Autor: | Jack M. Bernstein, Carol E. H. Scott-Conner, Kenneth S. Scher, Constance Bailey-Berk, James B. Grogan |
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| Rok vydání: | 1993 |
| Předmět: |
Male
medicine.medical_specialty Pathology Microbiological culture medicine.medical_treatment Intraperitoneal injection Spleen Bacteremia medicine.disease_cause Gastroenterology Rats Sprague-Dawley Phagocytosis Internal medicine Streptococcus pneumoniae medicine Animals Kidney Lung Cholestasis biology business.industry General Medicine Streptococcaceae biology.organism_classification Constriction Rats medicine.anatomical_structure Surgery Ligation business |
| Zdroj: | American journal of surgery. 166(3) |
| ISSN: | 0002-9610 |
| Popis: | Sprague-Dawley rats were challenged with intraperitoneal injection of 10(7) Streptococcus pneumoniae 10 days after common duct ligation (BDL) or sham celiotomy (SC). Quantitative bacterial cultures were performed on liver, spleen, lung, kidney, and heart blood samples obtained 4 hours after injection. All 13 (100%) BDL animals had positive heart blood cultures, but only 6 of 12 (50%) SC animals remained bacteremic (p0.05). Significantly more viable organisms were recovered from lung, liver, spleen, and kidney of BDL animals compared with SC controls. BDL impaired the host's ability to kill this encapsulated gram-positive organism. Viable bacteria remained in all organs studied, which was associated with continuing bacteremia. |
| Databáze: | OpenAIRE |
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