Biglycan expression in current cigarette smokers: a possible link between active smoking and atherogenesis
| Autor: | F. Mamone, Antonio Giovanni Versace, Antonino Saitta, C.O. Aragona, Giuseppe Mandraffino, Egidio Imbalzano, Giorgio Basile, Angela D'Ascola, Angela Alibrandi, M.A. Sardo, Antonella Cinquegrani, M. Cinquegrani, Scipione Carerj, Enrico Maria Mormina, A. Lo Gullo |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Male medicine.medical_specialty Pathology Adolescent Fibrinogen Systemic inflammation Carotid Intima-Media Thickness Polymerase Chain Reaction Monocytes Young Adult Biglycan Cigarette smoking Smoke exposure Vascular inflammation Vascular damage Risk Factors Internal medicine medicine Humans RNA Messenger Inflammation business.industry Interleukin-6 Smoking medicine.disease Atherosclerosis Peripheral Lipoproteins LDL Endocrinology C-Reactive Protein Carotid Arteries Cholesterol Intima-media thickness Quartile Arterial stiffness RNA Regression Analysis Female medicine.symptom Cardiology and Cardiovascular Medicine business medicine.drug Lipoprotein |
| Zdroj: | Atherosclerosis. 237(2) |
| ISSN: | 1879-1484 |
| Popis: | Objective : Cigarette smokers present early signs of vascular damage and systemic inflammation. Biglycan (BGN), an ubiquitous component of extracellular matrix orchestrating several physiological functions, has recently been indicated as a major source of low-density lipoprotein retention in the normal arterial intima-media layer. We evaluated whether BGN-mRNA expression was enhanced in peripheral monocytes of smokers with no additional cardiovascular risk factors (CVRFs), and if it was associated with altered carotid arterial stiffness (AS) or intima media thickness (cIMT). We also evaluated plasma markers of systemic and vascular inflammation, and correlation with BGN-mRNA. Methods : Two-hundred-fifty-one young smokers were enrolled, with no additional CVRFs, and 60 controls. Plasma lipids, fibrinogen, C-reactive protein (CRP), interleukin-6 (IL-6), AS and cIMT were assessed. A smoke exposure index (SEIx) was calculated. Results : Fibrinogen, CRP, AS indices, cIMT, and BGN-mRNA were higher in smokers compared to controls; HDL-C levels were lower, no difference was detected in IL-6 levels. After stratification of smokers in quartiles based on SEIx values, smokers in the highest quartiles presented highest fibrinogen, CRP, AS, cIMT, BGN, and also IL-6 values, and lowest HDL-C. Conclusion : BGN-mRNA was enhanced in young smokers, compared to controls, and appears associated to a proatherogenic profile, characterized by increased fibrinogen, CRP, and IL-6, lower HDL-C, altered AS and cIMT values, particularly in those with higher SEIx: the more cigarettes smoked over years, the more marked the alterations. Although we cannot state whether BGN have a direct causal role in inducing, maintaining and developing vascular damage, including intima-media wall thickening and arterial stiffening, our data could suggest that it may represent a link between proatherogenic status induced by cigarette smoking, and the development and progression of vascular damage. |
| Databáze: | OpenAIRE |
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