Interaction between Intracellular Bacterial Pathogens and Host Cell Mitochondria
| Autor: | Fabrizia Stavru, Anna Spier, Pascale Cossart |
|---|---|
| Přispěvatelé: | Interactions Bactéries-Cellules (UIBC), Institut National de la Recherche Agronomique (INRA)-Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM), Ecole doctorale Bio Sorbonne Paris Cité (BioSPC) (ED 157), Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5), Centre National de la Recherche Scientifique (CNRS), Institut National de la Recherche Agronomique (INRA)-Institut Pasteur [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut National de la Recherche Agronomique (INRA), Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Pasteur [Paris]-Institut National de la Recherche Agronomique (INRA) |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Cytoplasm
Physiology [SDV]Life Sciences [q-bio] Mitochondrion Mitochondrial Dynamics eputhelial-cells MESH: Animals rickettsii infection 0303 health sciences Ecology biology Effector 030302 biochemistry & molecular biology apoptosis MESH: Bacteria/pathogenicity MESH: Mitochondria/ultrastructure Mitochondria Cell biology MESH: Vacuoles/microbiology Infectious Diseases MESH: Cytoplasm/microbiology Host-Pathogen Interactions Intracellular Microbiology (medical) virulent mycobacterium-tuberculosis cytochrome-c release 03 medical and health sciences Immune system nf-kappa-b Genetics Animals Humans legionella-pneymophila 030304 developmental biology mocecular parhogenesis MESH: Humans Bacteria General Immunology and Microbiology ehrlichia-chaffeensis Intracellular parasite MESH: Host-Pathogen Interactions Cell Biology biology.organism_classification dependeny inhibition [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology MESH: Mitochondrial Dynamics Apoptosis Vacuoles MESH: Mitochondria/microbiology Function (biology) |
| Zdroj: | Microbiology Spectrum Microbiology Spectrum, 2019, Bacteria and Intracellularity, 7 (2), pp.3-13. ⟨10.1128/microbiolspec.BAI-0016-2019⟩ Microbiology Spectrum, American Society for Microbiology, 2019, Bacteria and Intracellularity, 7 (2), pp.3-13. ⟨10.1128/microbiolspec.BAI-0016-2019⟩ Bacteria and Intracellularity Microbiology Spectrum, American Society for Microbiology, 2019, 7 (2), ⟨10.1128/microbiolspec.BAI-0016-2019⟩ |
| ISSN: | 2165-0497 |
| DOI: | 10.1128/microbiolspec.BAI-0016-2019⟩ |
| Popis: | Mitochondria are essential and highly dynamic organelles whose morphology is determined by a steady-state balance between fusion and fission. Mitochondrial morphology and function are tightly connected. Because they are involved in many important cellular processes, including energy production, cell-autonomous immunity, and apoptosis, mitochondria present an attractive target for pathogens. Here, we explore the relationship between host cell mitochondria and intracellular bacteria, with a focus on mitochondrial morphology and function, as well as apoptosis. Modulation of apoptosis can allow bacteria to establish their replicative niche or support bacterial dissemination. Furthermore, bacteria can manipulate mitochondrial morphology and function through secreted effector proteins and can also contribute to the establishment of a successful infection, e.g., by favoring access to nutrients and/or evasion of the immune system. |
| Databáze: | OpenAIRE |
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