Improvement following interferon-alpha 2A in chronic inflammatory demyelinating polyneuropathy
| Autor: | Kenneth C. Gorson, Gregory Allam, Allan H. Ropper, Drasko Simovic |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Male
Injections Subcutaneous Neural Conduction Alpha interferon Chronic inflammatory demyelinating polyneuropathy Interferon alpha-2 Proinflammatory cytokine Sepsis Polyneuropathies Refractory Recurrence medicine Humans Prospective Studies Interferon alfa business.industry Interferon-alpha Middle Aged medicine.disease Recombinant Proteins Compound muscle action potential Treatment Outcome Chronic Disease Immunology Neurology (clinical) business Polyneuropathy Demyelinating Diseases medicine.drug |
| Zdroj: | Neurology. 48:777-780 |
| ISSN: | 1526-632X 0028-3878 |
| DOI: | 10.1212/wnl.48.3.777 |
| Popis: | Article abstract-Chronic inflammatory demyelinating polyneuropathy (CIDP) is a progressive or relapsing immune-mediated neuropathy usually responsive to plasma exchange, intravenous gammaglobulin or steroids, with some patients being refractory to these conventional therapies. We report a patient with CIDP who had spontaneous improvement after an episode of sepsis, but subsequently relapsed with severe generalized weakness; he was unresponsive to the conventional treatments for CIDP but had dramatic improvement following treatment with interferon-alpha 2A. Nerve conduction studies following treatment showed improved distal compound muscle action potential amplitudes without change in the degree of conduction block. The mechanism of action of interferon-alpha is unknown, but it may modulate proinflammatory cytokines that have a role in immune-mediated demyelination. Interferon-alpha may be an effective alternative therapy in patients with CIDP who relapse or are refractory to conventional treatments.NEUROLOGY 1997;48: 777-780 |
| Databáze: | OpenAIRE |
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