Non-canonical dimerization of the androgen receptor and other nuclear receptors: implications for human disease
| Autor: | Alba Jiménez-Panizo, Ana M. Rojas, Paloma Pérez, Eva Estébanez-Perpiñá, Pablo Fuentes-Prior |
|---|---|
| Přispěvatelé: | Red Nacional de Receptores Nucleares (España), Ministerio de Economía y Competitividad (España), Fundación 'la Caixa', Generalitat de Catalunya, European Commission, Fundación Bosch i Gimpera, Pérez, Paloma, Pérez, Paloma [0000-0002-7166-2824] |
| Rok vydání: | 2019 |
| Předmět: |
Male
0301 basic medicine Cancer Research Endocrinology Diabetes and Metabolism Receptors Cytoplasmic and Nuclear Estrogen receptor Glucocorticoid receptor Biology Ligand-binding domain 03 medical and health sciences Receptors Glucocorticoid 0302 clinical medicine Endocrinology Mineralocorticoid receptor Androgen insensitivity syndromes (AIS) Humans Hormone resistance Receptor Receptors Thyroid Hormone Prostate cancer Thyroid hormone receptor Prostatic Neoplasms Androgen-Insensitivity Syndrome Multimerization Androgen receptor Receptors Mineralocorticoid 030104 developmental biology Oncology Nuclear receptor Receptors Androgen 030220 oncology & carcinogenesis Protein structure Cancer research Steroids Protein Multimerization Receptors Progesterone Estrogen receptor alpha |
| Zdroj: | Digital.CSIC. Repositorio Institucional del CSIC instname |
| ISSN: | 1479-6821 1351-0088 |
| DOI: | 10.1530/erc-19-0132 |
| Popis: | 18 páginas, 5 figuras, 1 tabla Nuclear receptors are transcription factors that play critical roles in development, homeostasis and metabolism in all multicellular organisms. An important family of nuclear receptors comprises those members that respond to steroid hormones, and which is subdivided in turn into estrogen receptor (ER) isoforms α and β (NR3A1 and A2, respectively), and a second subfamily of so-called oxosteroid receptors. The latter includes the androgen receptor (AR/NR3C4), the glucocorticoid receptor (GR/NR3C1), the mineralocorticoid receptor (MR/NR3C2) and the progesterone receptor (PR/NR3C3). Here we review recent advances in our understanding of the structure-and-function relationship of steroid nuclear receptors and discuss their implications for the etiology of human diseases. We focus in particular on the role played by AR dysregulation in both prostate cancer (PCa) and androgen insensitivity syndromes (AIS), but also discuss conditions linked to mutations of the GR gene as well as those in a non-steroidal receptor, the thyroid hormone receptor (TR). Finally, we explore how these recent results might be exploited for the development of novel and selective therapeutic strategies. E E P expresses her deepest gratitude to the generous and continuous private donations from Gemma E Carretero. E E P, P F P and P P acknowledge the RED Nacional de Receptores Nucleares (NurCaMeIn: SAF2017-71878-REDT and SAF2015-71878-REDT). E E P acknowledges the BFU-Retos2017-86906-R, P F P the SAF2014-57994-R, P P the SAF2017-88046-R and A R the RTI2018-096735-B-100 grants from the MINECO. E E P and P F P are thankful for the CaixaImpulse2017 (ARDIs) from La Caixa (Fundación Bancaria Caja de Ahorros y Pensiones de Barcelona, Obra Social La Caixa y Caixa Risc) and SGR2017 and LLAVOR2018 grants from the Generalitat de Catalunya. E E P acknowledges the F2I-FVAL and F2I-MiR grants from the EU FEDER and the Fundació Bosch i Gimpera (FBG). |
| Databáze: | OpenAIRE |
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