Neuroendocrine tumors in the Iran Cancer Institute: predictive factors of patient survival
| Autor: | Mohammad Ali Mohagheghi, Ghodratollah Roshanaee, Easa Jahanzad, Alireza Mousavi-Jarahi, Sanambar Sadighi, Saba Vahedi |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Oncology
Male Cancer Research medicine.medical_specialty Epidemiology Carcinoid tumors medicine.medical_treatment Neuroendocrine tumors Adenocarcinoma Iran Internal medicine medicine Humans Neoplasm Invasiveness Retrospective Studies Chemotherapy Proportional hazards model business.industry Hazard ratio Public Health Environmental and Occupational Health Cancer Retrospective cohort study Patient survival Middle Aged medicine.disease Prognosis Combined Modality Therapy Surgery Survival Rate Neuroendocrine Tumors Lymphatic Metastasis Female Neoplasm Grading Neoplasm Recurrence Local business Follow-Up Studies |
| Zdroj: | Asian Pacific journal of cancer prevention : APJCP. 15(18) |
| ISSN: | 2476-762X |
| Popis: | Background: Neuroendocrine tumors have widespread and different clinical presentations and prognoses. This study was conducted to assess their survival time and prognostic factors in Iran. Materials and Methods: In a retrospective cohort study, 189 patients diagnosed of having neuroendocrine carcinoma were chosen. The tumor and clinical characteristics of the patients were modeled with a Cox proportional hazard approach. Survival was assessed using Kaplan-Meyer curves. Results: Crude median survival time was 30 months. Women survived longer than men (the median survival time for women was 40 and for men was 24 months). Age ( 60 years old with hazard ratio (HR) of 2.43, 95% CI 1.3-4.5), primary pathology report (carcinoid vs. others with HR 5.85 cm, 95% CI 2.4-14.3), tumor size cm (for 5-10, HR of 3.1, 95% CI 1.6 and for >10 HR of 8.2, 95% with 95% CI 3.1-21.9), and chemotherapy with single drug (taking vs. not taking with a HR 2.2, 95% CI 1.1-4.8) had significant effects on overall survival of patients. Conclusions: Survival time in patients with neuroendocrine carcinomas is related to demographics, clinical characteristics, tumor histology, and subtype specific treatment. |
| Databáze: | OpenAIRE |
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