A pilot study to assess markers of renal damage in the rodent kidney after exposure to 7 MHz ultrasound pulse sequences designed to cause microbubble translation and disruption
| Autor: | Kennita Johnson, Rachel E. Cianciolo, Ryan C. Gessner, Paul A. Dayton |
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| Rok vydání: | 2011 |
| Předmět: |
Male
Pathology medicine.medical_specialty Acoustics and Ultrasonics Biophysics Contrast Media Pilot Projects Kidney Article High-Energy Shock Waves Rats Sprague-Dawley medicine Animals Radiology Nuclear Medicine and imaging Acoustic radiation force Microbubbles Radiological and Ultrasound Technology Renal damage business.industry Pulse (signal processing) Ultrasound Acute kidney injury Acute Kidney Injury medicine.disease Rats medicine.anatomical_structure Molecular imaging business |
| Zdroj: | Ultrasound in medicinebiology. 38(1) |
| ISSN: | 1879-291X |
| Popis: | Acoustic radiation force has been proposed as a mechanism to enhance microbubble concentration for therapeutic and molecular imaging applications. It is hypothesized that once microbubbles are localized, bursting them with acoustic pressure could result in local drug delivery. It is known that low-frequency, high-amplitude acoustic energy combined with cavitation nuclei can result in bioeffects. However, little is known about the bioeffects potential of acoustic parameters involved in radiation force and microbubble destruction pulse sequences applied at higher frequencies. In this pilot study, rat kidneys are exposed to high-duty cycle, low-amplitude pulse sequences known to cause substantial bubble translation due to radiation force, as well as high-amplitude short pulse sequences known to cause microbubble destruction. Both studies are performed at 7 MHz on a clinical ultrasound system, and implemented in three-dimensions (3-D) for entire kidney exposure. Analysis of biomarkers of renal injury and renal histopathology indicate that there was no significant renal damage due to these ultrasound parameters in conjunction with microbubbles within the study group. |
| Databáze: | OpenAIRE |
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