Effects of birth size, post-natal growth and current size on insulin resistance in 9-year-old children: a prospective cohort study
Autor: | Bianca De Stavola, Vivienne M. Moore, Oana Maftei, Julie A. Owens, Lynne C. Giles, Melissa J. Whitrow, Michael J. Davies |
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Rok vydání: | 2013 |
Předmět: |
medicine.medical_specialty
Birth weight Childhood obesity Body Mass Index Child Development Insulin resistance Internal medicine medicine Birth Weight Humans Prospective Studies Child Prospective cohort study business.industry Infant Newborn Infant Gestational age medicine.disease Accelerated Growth Endocrinology Child Preschool Pediatrics Perinatology and Child Health Linear Models Insulin Resistance business Body mass index Follow-Up Studies Demography Cohort study |
Zdroj: | European Journal of Pediatrics. 172:1207-1214 |
ISSN: | 1432-1076 0340-6199 |
Popis: | The influence of pre-natal conditions on later type 2 diabetes risk factors such as insulin resistance (IR) may be mediated by post-natal growth trajectory. We aimed to investigate the association of body size at birth and 9 years with IR at 9 years. Using data from a prospective Australian cohort study, we examined the influence of body size from birth to 9 years [z-score for weight or body mass index (BMI)] on IR at 9 years (estimated by homeostasis model assessment). At age 9 years, 151 children provided a fasting blood sample. z-BMI at age 9 was positively associated with IR. Birth z-BMI was inversely associated with IR only after adjustment for z-BMI at age 9 years. This may be interpreted as an effect of accelerated growth between birth and 9 years on IR. There was a statistically significant interaction between birth and 9-year z-BMI. Results from regression models including z-BMI at all available time points (birth, 6 and 12 months, and 2, 3.5 and 9 years) indicate a possible inverse association between body size at 3.5 years and HOMA-IR at 9 years. Results were similar when the analyses were repeated with z-weight substituted for z-BMI. These results add to the body of evidence concerning the importance of growth in early life for later IR, and highlight a possible interaction between pre- and post-natal growth. The potential influence of growth at around 3.5 years for HOMA-IR at 9 years warrants further investigation. |
Databáze: | OpenAIRE |
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