The influence of interferon-γ on cardiac and renal histopathological changes induced by carbamazepine
| Autor: | Fatemeh Karimi, M. R. Namavar, A. Soleimani, S. Bahmanpour, M. Kamali |
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| Rok vydání: | 2018 |
| Předmět: |
Gastric gavage
Economics and Econometrics medicine.medical_specialty medicine.medical_treatment Intraperitoneal injection Kidney Benzodiazepines Interferon-gamma Mice Interferon γ Pregnancy Seizures Internal medicine Materials Chemistry Media Technology medicine Animals Fetus Epilepsy Hysterectomy business.industry Heart Forestry Carbamazepine medicine.anatomical_structure Endocrinology Gestation Anticonvulsants Female business medicine.drug |
| Zdroj: | Bratislava Medical Journal. 119:613-618 |
| ISSN: | 1336-0345 |
| Popis: | BACKGROUND Carbamazepine (CBZ) is used for the treatment of epileptic seizures. This study was designed to evaluate the effect of Interferon-gamma on the fetal heart and kidney histopathological changes of CBZ-treated pregnant mice. METHODS Twenty pregnant mice were divided into four groups. The control group received distilled water. The second group received 240 mg/kg of CBZ by gastric gavage. The third group received intraperitoneal injection (IP) of IFN-γ. The fourth group received IP injection of IFN-γ with 240 mg/kg CBZ by gavage. The fetuses were delivered by hysterectomy on the 18th day of gestation. RESULTS The mean weight, crown-rump length, the total volume of the heart and kidney of the fetuses in the CBZ-treated group were significantly reduced when compared with the control, INF-γ and CBZ + INF-γ groups (p < 0.05). INF-γ prevented histopathological changes when used with CBZ (p < 0.05). CONCLUSION CBZ induced structural changes in the fetal tissues of the pregnant mice. However, IFN-γ could reduce these changes (Tab. 1, Fig. 4, Ref. 26). |
| Databáze: | OpenAIRE |
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