Incremental Growth Lines in Mouse Molar Dentin Represent 8-hr Ultradian Rhythm
| Autor: | Yasuhiro Umemura, Toshiro Yamamoto, Hitoshi Inokawa, Narisato Kanamura, Yoshiki Tsuchiya, Nobuya Koike, Ryutaro Ono, Kazuhiro Yagita |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Molar
medicine.medical_specialty Histology Rodent Physiology Circadian clock circadian clocks Biochemistry Pathology and Forensic Medicine 03 medical and health sciences Rhythm stomatognathic system Internal medicine biology.animal medicine Dentin tooth tetracycline 030304 developmental biology Ultradian rhythm 0303 health sciences Chronobiology biology 030302 biochemistry & molecular biology Regular Article Cell Biology dentinogenesis stomatognathic diseases biological rhythms Endocrinology medicine.anatomical_structure Dentinogenesis |
| Zdroj: | Acta Histochemica et Cytochemica |
| ISSN: | 1347-5800 0044-5991 |
| DOI: | 10.1267/ahc.19017 |
| Popis: | Rhythmic incremental growth lines occur in dental hard tissues of vertebrates, and dentinogenesis in rodent incisors is suggested to be controlled by the 24-hr circadian clock. Rodent incisors continue to grow throughout the animal’s life; however, similar to human teeth, rodent molars stop growing after crown formation. This similarity suggests that the mouse molar is an excellent model to understand the molecular mechanisms underlying growth of human teeth. However, not much is known about the rhythmic dentinogenesis in mouse molars. Here, we investigated the incremental growth lines in mouse molar dentin using tetracycline as the growth marker. The incremental growth lines were observed to be generated at approximately 8-hr intervals in wild-type mice housed under 12:12 hr light-dark conditions. Moreover, the 8-hr rhythmic increments persisted in the wild-type and Bmal1−/− mice housed in constant darkness, where Bmal1−/− mice become behaviorally arrhythmic. These results revealed that the dentinogenesis in mouse molars underlie the ultradian rhythms with around 8-hr periodicity. Further, the circadian clock does not seem to be involved in this process, providing new insight into the mechanisms involved in the tooth growth. |
| Databáze: | OpenAIRE |
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