Pathological Correlations of Neuropsychiatric Symptoms in Institutionalized People with Dementia
| Autor: | Laura Amaya, Sofía Portela, Carlos Cátedra, Antonio Sánchez-Soblechero, Ester Esteban de Antonio, Javier Olazarán, Jorge López-Álvarez, Alberto Rábano, Luis Agüera-Ortiz |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Lewy Body Disease
Male medicine.medical_specialty Hallucinations Apathy Plaque Amyloid Neuropathology Anxiety Irritability Delusions Alzheimer Disease Internal medicine medicine Humans Dementia Pathological Depression (differential diagnoses) Aged Aged 80 and over Depression business.industry Dementia Vascular General Neuroscience Brain General Medicine medicine.disease Irritable Mood Aggression Psychiatry and Mental health Clinical Psychology Etiology Female Geriatrics and Gerontology medicine.symptom business |
| Zdroj: | Journal of Alzheimer's Disease. 78:1731-1741 |
| ISSN: | 1875-8908 1387-2877 |
| Popis: | Background: Comprehensive clinicopathological studies of neuropsychiatric symptoms (NPS) in dementia are lacking. Objective: To describe the pathological correlations of NPS in a sample of institutionalized people with dementia. Methods: We studied 59 people who were consecutively admitted to a nursing home and donated their brain. Correlations between pathological variables and NPS upon admission (n = 59) and at one-year follow-up assessment (n = 46) were explored and confirmed using bivariate and multivariate statistical methods. Results: Mean (SD) age at admission was 83.2 (6.4) years and mean (SD) age at demise was 85.4 (6.6); 73% of the subjects were female and 98% presented advanced dementia. The most frequent etiological diagnosis was Alzheimer’s disease (AD; 74.6% clinical diagnosis, 67.8% pathological diagnosis). The pathological diagnosis of AD was associated with aggression (β est 0.31), depression (β est 0.31), anxiety (β est 0.38), and irritability (β est 0.28). Tau stage correlated with aggressive symptoms (β est 0.32) and anxiety (βest 0.33). Coexistence of AD and Lewy body pathology was associated with depression (β est 0.32), while argyrophilic grains were associated with eating symptoms (β est 0.29). Predictive models were achieved for apathy, including cognitive performance, basal ganglia ischemic lesions, and sex as predictors (R2 0.38) and for sleep disorders, including pathological diagnosis of AD and age at demise (R2 0.18) (all p-values |
| Databáze: | OpenAIRE |
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