2(1H)-quinolinone derivatives as novel anti-arteriostenotic agents showing anti-thrombotic and anti-hyperplastic activities
| Autor: | Yukio Kimura, Kazuyuki Toga, Kazue Tachibana, Shirou Tochizawa, Koga Yasuo, Yoshito Kihara, Hiroyoshi Hidaka, Takao Nishi, Yoshihiro Inoue, Minoru Okada |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Hyperplasia
Bicyclic molecule Stereochemistry Arteriosclerosis Organic Chemistry Clinical Biochemistry Pharmaceutical Science Tetrazoles Thrombosis Quinolones Biochemistry Chemical synthesis Cilostazol chemistry.chemical_compound chemistry In vivo Drug Discovery Lactam Quinolines Molecular Medicine Animals Urea Rabbits Molecular Biology Platelet Aggregation Inhibitors |
| Zdroj: | Bioorganicmedicinal chemistry letters. 8(12) |
| ISSN: | 0960-894X |
| Popis: | In order to search for anti-arteriostenotic agents, a series of 2(1H)-quinolinone derivatives was synthesized and evaluated for anti-thrombotic activity and for anti-hyperplastic activity. From this series, (-)-6-[3-[3-cyclopropyl-3-[(1R,2R)-2-hydroxycyclohexyl]ureido]propoxy]-2 (1H)-quinolinone (1p, OPC-33509) was selected as the best candidate by balancing the efficacy on anti-thrombosis and anti-hyperplasia. |
| Databáze: | OpenAIRE |
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