Multicopy plasmids allow bacteria to escape from fitness trade-offs during evolutionary innovation
| Autor: | J. Carlos R. Hernandez-Beltran, Javier DelaFuente, Rafael Peña-Miller, Jose Antonio Escudero, Alvaro San Millan, R. Craig MacLean, Ayari Fuentes-Hernandez, Jerónimo Rodríguez-Beltrán |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Ecology Bacteria Functional redundancy Trade offs Genetic Fitness Model system Biology Biological Evolution Models Biological Article beta-Lactamases 03 medical and health sciences 030104 developmental biology Plasmid Phenotype Evolutionary biology Trait Escherichia coli Central element Gene Ecology Evolution Behavior and Systematics Plasmids |
| Zdroj: | Nature ecology & evolution Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid Consejería de Sanidad de la Comunidad de Madrid |
| ISSN: | 2397-334X |
| Popis: | Understanding the mechanisms governing innovation is a central element of evolutionary theory. Novel traits usually arise through mutations in existing genes, but trade-offs between new and ancestral protein functions are pervasive and constrain the evolution of innovation. Classical models posit that evolutionary innovation circumvents the constraints imposed by trade-offs through genetic amplifications, which provide functional redundancy. Bacterial multicopy plasmids provide a paradigmatic example of genetic amplification, yet their role in evolutionary innovation remains largely unexplored. Here, we reconstructed the evolution of a new trait encoded in a multicopy plasmid using TEM-1 β-lactamase as a model system. Through a combination of theory and experimentation, we show that multicopy plasmids promote the coexistence of ancestral and novel traits for dozens of generations, allowing bacteria to escape the evolutionary constraints imposed by trade-offs. Our results suggest that multicopy plasmids are excellent platforms for evolutionary innovation, contributing to explain their extreme abundance in bacteria. |
| Databáze: | OpenAIRE |
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