Intravenous Ilaprazole Is More Potent than Oral Ilaprazole Against Gastric Lesions in Rats
| Autor: | Xin-Qiang Lu, Rui-Bin Su, Xue-Mei Hou, Gang Yu, He-Zhi Xie, Ze-Hui Gong, Hai-Tang Hu |
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| Rok vydání: | 2014 |
| Předmět: |
Male
Physiology medicine.drug_class Indomethacin Proton-pump inhibitor Pharmacology Enteral administration 2-Pyridinylmethylsulfinylbenzimidazoles Esomeprazole Gastric Acid Rats Sprague-Dawley chemistry.chemical_compound Gastrointestinal Agents Stress Physiological Animals Medicine Potency Stomach Ulcer Oral therapy business.industry Ilaprazole Anti-Inflammatory Agents Non-Steroidal Stomach Gastroenterology Gastric lesions Rats chemistry Gastric Mucosa business Histamine medicine.drug |
| Zdroj: | Digestive Diseases and Sciences. 59:2417-2422 |
| ISSN: | 1573-2568 0163-2116 |
| DOI: | 10.1007/s10620-014-3187-2 |
| Popis: | Ilaprazole is a novel proton pump inhibitor that has been marketed as an oral therapy for acid-related diseases in China and Korea. This study aimed to compare the gastroprotective effects of intravenous and enteral ilaprazole in rat models. The rats were divided into 7–8 groups receiving vehicle, esomeprazole, and different doses of intravenous and enteral ilaprazole. The rats were then exposed to indomethacin (30 mg/kg, i.g.), or water-immersion stress and gastric lesions were examined. The effects of different treatments on histamine (10 μmol/kg/h)-induced acid secretion were also observed. Intravenous ilaprazole exhibited high antiulcer activity in a dose-dependent manner. Ilaprazole at a dose of 3 mg/kg decreased ulcer number and index to the same extent as 20 mg/kg esomeprazole. Moreover, the potency of intravenous ilaprazole is superior to that of intragastric ilaprazole. In anesthetized rats, the inhibitory effect of intravenous ilaprazole on histamine-induced acid secretion is faster and longer-lasting than that of intraduodenal ilaprazole. Intravenous ilaprazole is more potent than oral ilaprazole against indomethacin- or stress-induced gastric lesions, with faster and longer inhibition of acid secretion. |
| Databáze: | OpenAIRE |
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