The structure of the S-layer of Clostridium difficile
| Autor: | April K. Roberts, Clifford C. Shone, William J. Bradshaw, K. Ravi Acharya |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Clostridium Difficile Drug target Bacterial adhesion Review Biochemistry S-layer Microbiology 03 medical and health sciences medicine Colitis Molecular Biology Pathogen biology Cell wall protein Antibiotic-associated diarrhoea Cell Biology Clostridium difficile biology.organism_classification medicine.disease 3. Good health 030104 developmental biology C. difficile Infection Protein microarray Bacteria |
| Zdroj: | Journal of Cell Communication and Signaling |
| ISSN: | 1873-961X 1873-9601 |
| Popis: | The nosocomially acquired pathogen Clostridium difficile is the primary causative agent of antibiotic associated diarrhoea and causes tens of thousands of deaths globally each year. C. difficile presents a paracrystalline protein array on the surface of the cell known as an S-layer. S-layers have been demonstrated to possess a wide range of important functions, which, combined with their inherent accessibility, makes them a promising drug target. The unusually complex S-layer of C. difficile is primarily comprised of the high- and low- molecular weight S-layer proteins, HMW SLP and LMW SLP, formed from the cleavage of the S-layer precursor protein, SlpA, but may also contain up to 28 SlpA paralogues. A model of how the S-layer functions as a whole is required if it is to be exploited in fighting the bacterium. Here, we provide a summary of what is known about the S-layer of C. difficile and each of the paralogues and, considering some of the domains present, suggest potential roles for them. |
| Databáze: | OpenAIRE |
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