Six-Minute Walk Distance Predictors, Including CT Scan Measures, in the COPDGene Cohort
| Autor: | Marilyn Foreman, Raul San Jose Estepar, Janos Porszasz, Marci Sontag, Gregory Kinney, Frank Sciurba, Eric Hoffman, Robert Wise, Jeffrey Curtis |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Male
Pulmonary and Respiratory Medicine Spirometry medicine.medical_specialty SIX MINUTE WALK Time Factors Computed tomography Walking Critical Care and Intensive Care Medicine Pulmonary Disease Chronic Obstructive Forced Expiratory Volume Internal medicine medicine Humans Stage (cooking) Original Research Aged Aged 80 and over Emphysema COPD Exercise Tolerance Lung medicine.diagnostic_test business.industry Smoking Middle Aged medicine.disease Obstructive lung disease respiratory tract diseases medicine.anatomical_structure Cohort Physical therapy Female Tomography X-Ray Computed Cardiology and Cardiovascular Medicine business |
| Zdroj: | Chest. 141:867-875 |
| ISSN: | 0012-3692 |
| Popis: | Exercise tolerance in COPD is only moderately well predicted by airflow obstruction assessed by FEV(1). We determined whether other phenotypic characteristics, including CT scan measures, are independent predictors of 6-min walk distance (6MWD) in the COPDGene cohort.COPDGene recruits non-Hispanic Caucasian and African American current and ex-smokers. Phenotyping measures include postbronchodilator FEV(1) % predicted and inspiratory and expiratory CT lung scans. We defined % emphysema as the percentage of lung voxels-950 Hounsfield units on the inspiratory scan and % gas trapping as the percentage of lung voxels-856 Hounsfield units on the expiratory scan.Data of the first 2,500 participants of the COPDGene cohort were analyzed. Participant age was 61 ± 9 years; 51% were men; 76% were non-Hispanic Caucasians, and 24% were African Americans. Fifty-six percent had spirometrically defined COPD, with 9.3%, 23.4%, 15.0%, and 8.3% in GOLD (Global Initiative for Chronic Obstructive Lung Disease) stages I to IV, respectively. Higher % emphysema and % gas trapping predicted lower 6MWD (P.001). However, in a given spirometric group, after adjustment for age, sex, race, and BMI, neither % emphysema nor % gas trapping, or their interactions with FEV(1) % predicted, remained a significant 6MWD predictor. In a given spirometric group, only 16% to 27% of the variance in 6MWD could be explained by age, male sex, Caucasian race, and lower BMI as significant predictors of higher 6MWD.In this large cohort of smokers in a given spirometric stage, phenotypic characteristics were only modestly predictive of 6MWD. CT scan measures of emphysema and gas trapping were not predictive of 6MWD after adjustment for other phenotypic characteristics. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|