New compounds inhibiting lipid accumulation from the stems of Sabia parviflora
| Autor: | Yuwei Wang, Fan Donghui, Zhifeng Li, Qi Wang, Lingling Pan, Shilin Yang, Yulin Feng |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Lipid accumulation
Stereochemistry 01 natural sciences Cell Line Palmitic acid chemistry.chemical_compound Drug Discovery medicine Humans Sabia parviflora Hypolipidemic Agents Pharmacology Molecular Structure Plant Stems 010405 organic chemistry Cell model General Medicine medicine.disease Circular dichroism spectra Nmr data 0104 chemical sciences Tracheophyta 010404 medicinal & biomolecular chemistry Oleic acid chemistry Hepatocytes Steatosis |
| Zdroj: | Fitoterapia. 128:218-223 |
| ISSN: | 0367-326X |
| DOI: | 10.1016/j.fitote.2018.05.021 |
| Popis: | Four new compounds, sabianin A (1), sabianin B (2), sabianin C, (3) and sabianin D (4) together with seven known compounds (5–11) were isolated from the stems of Sabia parviflora. The structures of these compounds were elucidated by extensive spectroscopic analysis and by comparing their NMR data with those of related compounds. Their absolute configurations were determined by comparing the calculated and experimental electronic circular dichroism spectra. The lipid-lowering effect of all the compounds was evaluated using a cell model of steatosis induced by oleic acid and palmitic acid. Compounds 3, 6, and 10 showed statistically significant lipid-lowering effect. |
| Databáze: | OpenAIRE |
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