Clinical validation of the iXip index in avoiding unnecessary prostate biopsy: Results from a prospective multicenter study involving 426 patients
| Autor: | Gianluca Giannarini, Danilo Zani, Lucio Laurini, A. Garbeglio, Filiberto Zattoni, Mario Plebani, Andrea Gallotta, Giorgio Fassina, S. Guazzieri |
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| Rok vydání: | 2017 |
| Předmět: |
Oncology
PCA3 Cancer Research medicine.medical_specialty Prostate biopsy 030232 urology & nephrology prostatic neoplasm PSA 03 medical and health sciences Prostate cancer 0302 clinical medicine Prostate Internal medicine Biopsy Medicine prostate biopsy Prostate Health Index Prostate CAncer Gene 3 medicine.diagnostic_test business.industry PSA-IgM Cancer biomarker diagnostic accuracy iXip medicine.disease medicine.anatomical_structure Multicenter study 030220 oncology & carcinogenesis Biomarker (medicine) business |
| Zdroj: | Cancer Treatment and Research Communications. 10:40-45 |
| ISSN: | 2468-2942 |
| Popis: | Purpose To assess the diagnostic accuracy of iXip, a novel biomarker for prostate cancer detection at initial biopsy based on an algorithm including patient age, prostate volume, PSA and PSA-IgM levels,. Materials and methods This was a prospective multicenter study involving 426 consecutive men undergoing initial prostate biopsy with at least 12 cores in a real-life clinical setting. Diagnostic accuracy of iXip for prostate cancer detection was calculated with AUC and compared to that of prostate volume, PSA and PSA-IgM levels. The correlation of iXip with tumor aggressiveness, defined as any cancer with Gleason score ≥7, was evaluated by Spearman ρ coefficient analysis. Results Prostate cancer was diagnosed in 193/426 patients (45%), of which 65 (35%) had Gleason score ≥7. iXip values were significantly higher in patients with cancer than in those without cancer (median value 55% vs. 39%, p Conclusions Our prospective multicenter study suggests that the novel biomarker iXip may be used with a 20% cut-off value in order to reduce the proportion of prostate biopsies by approximately 5%, without missing a single case of cancer. Moreover, higher iXip values are significantly correlated with tumor aggressiveness. |
| Databáze: | OpenAIRE |
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