Circulating Levels of Thrombospondin-1 and Thrombospondin-2 in Patients with Common Brain Tumors
| Autor: | Sureyya Toklu, Bagnu Orhan, Tibet Kacira, Berkay Aktas, Mehmet Yigit Akgun, Berrin Bercik Inal, Taner Tanriverdi, Taha Sukru Korkmaz, Seckin Aydin, Rahsan Kemerdere |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Oncology
Adult Male endocrine system medicine.medical_specialty Angiogenesis Growth-Factor-Beta Expression Brain tumors Malignant transformation Meningioma Thrombospondin 1 Text mining Internal medicine Glioma Meningeal Neoplasms Medicine Humans Prospective Studies Prospective cohort study neoplasms Inhibition Aged Thrombospondin business.industry Brain Neoplasms virus diseases Cancer Middle Aged medicine.disease nervous system diseases Surgery Female Neurology (clinical) business Thrombospondins |
| Zdroj: | Turkish neurosurgery. 31(3) |
| ISSN: | 1019-5149 |
| Popis: | Aim Angiogenesis is linked to the development of cancer and plays an important role in tumor growth and malignant transformation. Thrombospondin-1 (TSP-1) and thrombospondin-2 (TSP-2) are potent angiostatic molecules that were highly expressed in developing blood vessels. The objective of this study is to measure serum levels of TSP-1 and TSP-2 in patients with common brain tumors, namely high-grade glioma (HGG), low-grade glioma (LGG), and meningioma. Material and methods For this prospective study, a total of 56 patients were operated on for supratentorial gliomas and meningiomas, and 18 healthy subjects were evaluated. Serum levels of angiostatic molecules were measured with enzyme-linked immunosorbent assay. The results of patients were compared with those of healthy subjects. Results High serum levels of TSP-1 were seen in HGG, followed by LGG, meningioma groups, and controls. The only significant difference was found between HGGs and controls (p = 0.004). There was a trend to decrease from HGG to controls. High serum levels of TSP-2 were seen in controls, followed by meningioma, LGG, and HGG. None of the patient groups showed significant differences compared with controls. Among the patient groups, TSP-2 was significantly higher in the meningioma group than the HGG group (p = 0.01). No correlation was found with any of the molecules and the clinical parameters, including the presence of peritumoral edema or seizure, the anterior-posterior diameter of the tumor, and, more importantly, the grade of glioma. Conclusion Our results indicate that TSP-2 might be more important than TSP-1 in preventing angiogenesis and a major angiostatic factor in glioma cells. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|