Surveillance of HIV and viral hepatitis by analysis of samples from drug related deaths
| Autor: | Kari Grasaasen, Peer Brehm Christensen, Jørgen Georgsen, Gitte Wulf Jürgensen, Court Pedersen, Susan Cowan, Birgitte Kringsholm, Jytte Banner, Jørgen Lange Thomsen, Gabriela Felicia Stein |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2006 |
| Předmět: |
Adult
Male drug related deaths Postmortem testing viral hepatitis epidemiology medicine.medical_specialty Hepatitis B virus Epidemiology Substance-Related Disorders Denmark HIV Infections Hepacivirus Antiviral Agents Acquired immunodeficiency syndrome (AIDS) medicine Humans Registries Sida biology business.industry virus diseases HIV Hepatitis C Hepatitis B Middle Aged biology.organism_classification medicine.disease Virology digestive system diseases Lentivirus Female Viral disease Autopsy business Viral hepatitis |
| Zdroj: | Christensen, P B, Kringsholm, B, Banner, J, Thomsen, J L, Cowan, S, Stein, G, Jurgensen, G, Grasaasen, K, Georgsen, J & Pedersen, C 2006, ' Surveillance of HIV and viral hepatitis by analysis of samples from drug related deaths ', European Journal of Epidemiology, vol. 21, no. 5, pp. 383-387 . Christensen, P B, Kringsholm, B, Banner, J, Thomsen, J, Cowan, S, Stein, G F, Jürgensen, G W, Grasaasen, K, Georgsen, J & Pedersen, C 2006, ' Surveillance of HIV and viral hepatitis by analysis of samples from drug related deaths ', European Journal of Epidemiology, vol. 21, no. 5, pp. 383-387 . University of Southern Denmark |
| Popis: | To determine the prevalence of antibodies against HIV, hepatitis B (HBV) and hepatitis C (HCV) in postmortem samples from drug related deaths (DRDs) in Denmark.Prospective cohort study. Postmortem samples tested for anti-HIV, anti-HCV anti-HBc and anti-HBs. Comparison to pre-mortem testing when possible. DRDs were searched for in the national register of drug treatment, national prison registers, and the national infectious disease register.National level.Drug related deaths admitted to Danish Institutes of Forensic Medicine during 2004.Prevalence of antibodies, injection drug use, drug treatment experience and prevalence of cirrhosis.Samples for analysis were obtained from 78% (233/299) of DRDs. The prevalences of anti-HIV, anti-HCV and anti-HBc were 4% (9/214), 51% (110/215), and 35% (74/209), indicating a persisting low prevalence of HIV and a declining prevalence of HCV and HBV. Injecting ever was detected among 45% of DRDs and this was associated with a significantly higher prevalence of hepatitis B and C. Among the DRDs 56% received drug treatment and 12% had cirrhosis at autopsy. Evidence of vaccination against HBV was found among 16% (21/128).Monitoring of viral hepatitis and HIV among DRDs is feasible, and our survey indicates a falling prevalence among Danish drug users. Surveillance based on drug users in treatment may overestimate the true prevalence. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|