Role of nitric oxide in the maintenance of pluripotency and regulation of the hypoxia response in stem cells
| Autor: | Carmen Salguero-Aranda, Bernat Soria, Juan R. Tejedo, Amparo Beltran-Povea, Franz Martín, Estefanía Caballano-Infantes, Gladys M. Cahuana, Francisco J. Bedoya |
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| Přispěvatelé: | Junta de Andalucía, European Commission, Red de Terapia Celular (España), Ministerio de Sanidad y Consumo (España), Ministerio de Economía y Competitividad (España) |
| Rok vydání: | 2015 |
| Předmět: |
Pluripotency
Cell type Histology Cellular differentiation Regulator Review Biology Bioinformatics Nitric oxide chemistry.chemical_compound Gene expression Genetics Hypoxia Molecular Biology Cell potency Genetics (clinical) Stem cell Cell Biology Embryonic stem cell Cell biology Metabolism chemistry Differentiation |
| Zdroj: | Digital.CSIC. Repositorio Institucional del CSIC instname |
| ISSN: | 1948-0210 1556-8539 |
| Popis: | Stem cell pluripotency and differentiation are global processes regulated by several pathways that have been studied intensively over recent years. Nitric oxide (NO) is an important molecule that affects gene expression at the level of transcription and translation and regulates cell survival and proliferation in diverse cell types. In embryonic stem cells NO has a dual role, controlling differentiation and survival, but the molecular mechanisms by which it modulates these functions are not completely defined. NO is a physiological regulator of cell respiration through the inhibition of cytochrome c oxidase. Many researchers have been examining the role that NO plays in other aspects of metabolism such as the cellular bioenergetics state, the hypoxia response and the relationship of these areas to stem cell stemness Supported by Grants from Consejería de Igualdad, Salud y Politicas Sociales, Junta de Andalucía, No. PI105/2010; and Consejería de Economía, Innovación, Ciencia y Empleo, Junta de Andalucía, No. CTS-7127/2011 (to Bedoya FJ); Consejería de Igualdad, Salud y Políticas Sociales, Junta de Andalucía, ISCIII co-funded by Fondos FEDER (RED TERCEL), No. RD06/0010/0025, RD12/0019/0028 and PI10/00964; Consejería de Economía, Innovación, Ciencia y Empleo, No. P10.CTS.6505; and the Ministry of Health and Consumer Affairs (Advanced Therapies Program Grant TRA-120) (to Soria B); Consejería de Igualdad, Salud y Políticas Sociales, No. PI0022/2008; and Consejería de Economía, Innovación, Ciencia y Empleo, Junta de Andalucía (PAI, BIO311) (to Martín F); Servicio Andaluz de Salud (SAS 11245) and Ministerio de Economía y Competitividad-Secretaría de Estado de Investigación Desarrollo e Innovación, No. IPT-2011-1615-900000 (to Tejedo JR). |
| Databáze: | OpenAIRE |
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