Combined Alpha-interferon and Ribavirin Treatment in Chronic Hepatitis C: A Pilot Study
| Autor: | Katarina Engman, Jean Henrik Braconier, Anders Widell, Otto Paulsen |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Adult
Male Microbiology (medical) medicine.medical_specialty Combination therapy Molecular Sequence Data Alpha interferon Pilot Projects Hepacivirus Antiviral Agents Polymerase Chain Reaction Gastroenterology Virus chemistry.chemical_compound Internal medicine Ribavirin Humans Medicine Interferon alfa Depression (differential diagnoses) Aged Hepatitis Chronic Base Sequence General Immunology and Microbiology business.industry Interferon-alpha Alanine Transaminase General Medicine Middle Aged Hepatitis C Treatment Outcome Infectious Diseases chemistry Immunology Toxicity RNA Viral Drug Therapy Combination Female Viral disease business medicine.drug |
| Zdroj: | Scandinavian Journal of Infectious Diseases. 27:325-329 |
| ISSN: | 1651-1980 0036-5548 |
| Popis: | 16 patients with chronic hepatitis C virus (HCV) infection were treated with a combination of interferon-alpha and ribavirin for 24 weeks in an open study. One patient declined further treatment due to depression after week 16 and did not complete further follow-up. A moderate decline was observed in hemoglobin and an increase in bilirubin level both reversible after discontinuing the treatment. 24 weeks after treatment cessation 9/15 (60%) evaluable patients had complete clearance of HCV-RNA as measured with PCR. HCV genotype did not seem to be correlated with response, but patients with sustained response to treatment had a significantly reduced number of HCV RNA copies/ml serum at treatment start compared with the other patients. These findings support the promising results of this combination therapy noted in other pilot studies. |
| Databáze: | OpenAIRE |
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