Salt and phytochemical assisted modulation of self-assembly characteristics of Polysorbate-80 in aqueous medium
| Autor: | Sukhendu Nath, Sugam Kumar, Rajib Ganguly, Vinod K. Aswal |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Curcumin
Alginates Phytochemicals Polysorbates Pharmaceutical Science Salt (chemistry) Lavender oil 02 engineering and technology Sodium Chloride 030226 pharmacology & pharmacy Micelle Polyvinyl alcohol 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Oils Volatile Plant Oils Micelles chemistry.chemical_classification Aqueous solution Chemistry Vesicle Hydrogels 021001 nanoscience & nanotechnology Lavandula Solubility Phytochemical Chemical engineering Micellar solutions Rheology 0210 nano-technology |
| Zdroj: | International Journal of Pharmaceutics. 563:63-70 |
| ISSN: | 0378-5173 |
| DOI: | 10.1016/j.ijpharm.2019.03.055 |
| Popis: | Polysorbate 80 is one of the most widely used solubilizing agents in food, cosmetic and pharmaceutical industries. Influences of different classes of solubilizates and additives on its self-assembly characteristics are however, not sufficiently understood yet. In this manuscript, we show how common water structure making salt NaCl, and lipophilic phytochemicals like curcumin and lavender oil help in modulating the structure of Polysorbate 80 micelles in aqueous medium. Our DLS, SANS and rheological studies show that NaCl induces sphere-to-rod growth of polysorbate 80 micelles at the room temperature. Micellar solubilizations of the phytochemicals, which were found to be facilitated with increase in temperature, induce only a marginal growth of the micelles up to the highest level of solubilization. Their presence however, helps in modulating the NaCl induced micellar growth behavior in the tween 80 solutions leading to observation of micelle-to-vesicle structural transition at 2% lavender oil concentration. The phytochemical solubilized micellar solutions could be converted to alginate based hydrogel beads and patches that can freely release micellar phytochemical in aqueous medium. Our results shed light on possible ways of modulating the solubilization behavior, self-assembly characteristics and rheological properties of aqueous system of polysorbate 80, which could be important for their applications. |
| Databáze: | OpenAIRE |
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