Changes in Age at Diagnosis and Nutritional Course of Celiac Disease in the Last Two Decades
| Autor: | Bárbara Leyton, Mónica Villanueva, Mónica González, Amaya Oyarzún, Cristobal Ossa, Magdalena Araya, María Paz Muñoz, Karla A. Bascuñán, Elizabeth Navarro, Paulina Canales |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty Pediatrics Pediatric Obesity Gastrointestinal Diseases Nutritional Status lcsh:TX341-641 Disease Overweight Weight Gain Asymptomatic Article Body Mass Index 03 medical and health sciences Diet Gluten-Free 0302 clinical medicine Thinness 030225 pediatrics medicine Prevalence follow up Humans Chile Child Autoantibodies Nutrition and Dietetics business.industry Public health Age Factors nutritional and metabolic diseases Infant medicine.disease Obesity digestive system diseases Hospitals Failure to Thrive Malnutrition Celiac Disease age Child Preschool Failure to thrive 030211 gastroenterology & hepatology Female Presentation (obstetrics) medicine.symptom business lcsh:Nutrition. Foods and food supply Food Science |
| Zdroj: | Nutrients Volume 12 Issue 1 Nutrients, Vol 12, Iss 1, p 156 (2020) |
| ISSN: | 2072-6643 |
| Popis: | The frequency of celiac disease (CD) has increased along time, with relevant changes reported in geographical variations, clinical presentation and nutritional repercussions. In recent years, some celiac patients are presenting overweight/obesity, but it is unclear how frequent this is and to what extent undernutrition remains a concern. This is relevant because CD tends to be overlooked in overweight patients. With this in mind, we assessed age at diagnosis, clinical characteristics and nutritional status of 155 celiac patients diagnosed between 1994&ndash 2017 in four pediatric hospitals in Santiago, Chile. Since 2003, the number of patients diagnosed has increased (p < 0.0033), coinciding with antitransglutaminase and antiendomysial antibodies becoming available to public health systems. In 2000, 4.5% of patients were asymptomatic at diagnosis, suggesting that active search is not routinely applied. Gastrointestinal symptoms plus failure to thrive were significantly more frequent under 2 years (p = 0.0001). Nutritional status has improved at diagnosis and during follow up, but undernutrition remains more frequent in children < 2 and < 5 years (p < 0.002 and p < 0.0036, respectively). Overweight at diagnosis was reported in 2002 and obesity in 2010. After initiating treatment, since 2010, patients changing from undernourishment to overweight has sometimes been observed after only 6 months on a gluten-free diet. |
| Databáze: | OpenAIRE |
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