Potential Association of Doxycycline With the Onset of Primary Sclerosing Cholangitis: A Case Series
Autor: | Kenneth L. Cox, Keith D. Lindor, Ahmad H. Ali, James Gage Buness, James H. Tabibian, Cynthia W Buness |
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Rok vydání: | 2022 |
Předmět: |
Adult
Male medicine.medical_specialty endocrine system diseases medicine.drug_class Cholangitis Sclerosing Antibiotics 030204 cardiovascular system & hematology digestive system Gastroenterology Primary sclerosing cholangitis Young Adult 03 medical and health sciences 0302 clinical medicine Risk Factors Internal medicine medicine Humans Pharmacology (medical) 030212 general & internal medicine Pharmacology Doxycycline Patient registry business.industry digestive oral and skin physiology Inflammatory Bowel Diseases General Medicine medicine.disease Ulcerative colitis digestive system diseases Gut microbiome Median time Colitis Ulcerative Female business medicine.drug |
Zdroj: | American Journal of Therapeutics. 29:e437-e443 |
ISSN: | 1075-2765 |
Popis: | Background Primary sclerosing cholangitis (PSC) is linked to inflammatory bowel diseases (IBD). Evidence suggests an association between the gut microbiome and PSC. However, the putative relationship between exposure to antibiotics and onset of PSC has never been reported. We observed 3 cases in which patients without antecedent liver or bowel issues developed symptoms leading to diagnosis of IBD and subsequently PSC after being exposed to doxycycline. We aimed to identify, through the PSC Partners national patient registry, additional cases of PSC in which there is a temporal relationship between exposure to doxycycline and onset of PSC or PSC-IBD. Areas of uncertainty The etiopathogenesis of PSC remains an enigma. Data sources We collected data from patients with PSC and PSC-IBD in which there seemed to be a temporal relationship between exposure to doxycycline and PSC. Time from doxycycline exposure to: (1) onset of PSC or PSC-IBD symptoms and (2) diagnosis of PSC were documented for each patient. Descriptive statistical analyses were performed. Results We identified 6 additional patients with PSC or PSC-IBD in whom there was a temporal relationship between exposure to doxycycline and onset of PSC or PSC-IBD. The median age of these 9 patients was 20 years, 6 were female, and 7 had ulcerative colitis. The median time from doxycycline exposure to onset of first symptoms was 3 months, and median time from doxycycline exposure to diagnosis of PSC was 15 months. Therapeutic hypothesis We describe 9 cases of PSC and PSC-IBD in which there seem to be a temporal relationship between exposure to doxycycline and onset of PSC. |
Databáze: | OpenAIRE |
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