Autologous Chondrocyte Transplantation
| Autor: | Evy Lundgren Åkerlund, Illka Kiviranta, Anders Lindahl, Lars Peterson, Mats Brittberg |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Adult
Cartilage Articular Male medicine.medical_specialty Pathology Adolescent Biopsy Statistics as Topic Type II collagen Physical Therapy Sports Therapy and Rehabilitation Knee Injuries Transplantation Autologous Chondrocyte Arthroscopy 03 medical and health sciences Chondrocytes 0302 clinical medicine medicine Humans Orthopedics and Sports Medicine Femur Anterior Cruciate Ligament Autologous chondrocyte implantation Hyaline Cartilage oligomeric matrix protein 030222 orthopedics biology business.industry Cartilage Graft Survival Articular cartilage injuries Patella 030229 sport sciences Middle Aged medicine.disease Osteochondritis Dissecans Biomechanical Phenomena Surgery Transplantation Treatment Outcome medicine.anatomical_structure Second-Look Surgery biology.protein Female business Follow-Up Studies |
| Zdroj: | The American Journal of Sports Medicine. 30:2-12 |
| ISSN: | 1552-3365 0363-5465 |
| Popis: | We evaluated the durability of autologous chondrocyte transplantation grafts in 61 patients treated for isolated cartilage defects on the femoral condyle or the patella and followed up for a mean of 7.4 years (range, 5 to 11). Durability was determined by comparing the clinical status at the long-term follow-up with that found 2 years after the transplantation. After 2 years, 50 of the 61 patients had good or excellent clinical results, and 51 of 61 had good or excellent results at 5 to 11 years later. Grafted areas from 11 of the patients were evaluated with an electromechanical indentation probe during a second-look arthroscopy procedure (mean follow-up, 54.3 months; range, 33 to 84); stiffness measurements were 90% or more of those of normal cartilage in eight patients. Eight of twelve 2-mm biopsy samples taken from these patients showed hyaline characteristics with safranin O staining and a homogeneous appearance in polarized light. Three fibrous and eight hyaline biopsy specimens stained positive to aggrecan and to cartilage oligomeric matrix protein. Hyaline-like specimens stained positive for type II collagen, and fibrous, for type I collagen. Autologous chondrocyte transplantation for the treatment of articular cartilage injuries has a durable outcome for as long as 11 years. |
| Databáze: | OpenAIRE |
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