Acute Tubular Necrosis and Renal Failure in Patients with Glomerular Disease
| Autor: | Maria da Conceição Chagas de Almeida, Ana Carolina Gil Pinho de Sousa, Maria Brandão Tavares, Reinaldo Martinelli, Washington Luis Conrado dosSantos, Reyla Tarita Cruz Martins |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Adolescent Urology glomerular disease Critical Care and Intensive Care Medicine urologic and male genital diseases Young Adult Focal segmental glomerulosclerosis Glomerulonephritis Glomerulopathy histological score medicine Humans Minimal change disease Renal Insufficiency Child Acute tubular necrosis Aged Kidney medicine.diagnostic_test business.industry nephrotic syndrome Glomerulosclerosis Focal Segmental Acute kidney injury Infant General Medicine Kidney Tubular Necrosis Acute Middle Aged medicine.disease medicine.anatomical_structure acute kidney injury acute tubular necrosis Nephrology Child Preschool Clinical Study histopathology Female Renal biopsy business Nephrotic syndrome |
| Zdroj: | Renal Failure |
| ISSN: | 1525-6049 0886-022X |
| Popis: | Renal failure is common in patients with glomerular disease. Although renal failure may result from the glomerular lesion itself, it is also observed in patients with minimal glomerular alterations. Degenerative changes and necrosis of the tubular epithelium are common findings in kidney biopsies from these patients. The aim of this work is to examine the association between acute tubular necrosis (ATN) and renal failure in patients with glomerulopathy and to estimate the relationship between the degree of ATN and renal failure in these patients. Data on age, sex, presence of nephrotic syndrome, and renal failure were recorded for 149 patients, who underwent a renal biopsy for the diagnosis of glomerulopathy. The biopsies were reviewed, and ATN, when present, was classified as one of four grades depending on its intensity. The mean age of the patients was 21 ± 16 years. Eighty patients (54%) were male, 43 (42%) had renal failure, 104 (72%) had nephrotic syndrome, and 66 (45%) had minimal change disease or focal segmental glomerulosclerosis. ATN was present in 115 (77%) patients. The frequency of renal failure was directly correlated with the intensity of ATN [odds ratio (OR) of 26.0 for patients with grade 2 lesions and OR of 45.5 for patients with grade 3 lesions]. ATN is a common finding in the biopsies of patients with glomerulopathy. The severity of ATN is directly associated with the frequency of renal failure in these patients. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
| Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |