Efficacy and safety of recombinant human follicle stimulating hormone (Gonal-F) with urinary human chorionic gonadotrophin for induction of spermatogenesis and fertility in gonadotrophin-deficient men
| Autor: | David J. Handelsman, H.W. Gordon Baker, Leo Turner, Debra Rushford, Peter Liu, Ann J. Conway, Jillian McDonald |
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| Rok vydání: | 1999 |
| Předmět: |
Adult
Male endocrine system Adolescent medicine.drug_class media_common.quotation_subject Fertility Biology Chorionic Gonadotropin Andrology Follicle-stimulating hormone Pregnancy Semen Hypogonadotropic hypogonadism Testis medicine Humans Testosterone Prospective Studies Spermatogenesis Infertility Male reproductive and urinary physiology media_common Estradiol Sperm Count Rehabilitation Obstetrics and Gynecology Middle Aged medicine.disease Sperm Recombinant Proteins Reproductive Medicine Estrogen Gonadotropins Pituitary Sperm Motility Female Follicle Stimulating Hormone Human Follicle Stimulating Hormone Gonadotropin hormones hormone substitutes and hormone antagonists |
| Zdroj: | Human Reproduction. 14:1540-1545 |
| ISSN: | 1460-2350 0268-1161 |
| DOI: | 10.1093/humrep/14.6.1540 |
| Popis: | In order to evaluate the efficacy and safety of recombinant human follicle stimulating hormone (r-hFSH) in combination with urinary human chorionic gonadotrophin (HCG) to induce spermatogenesis and fertility in gonadotrophin-deficient men, we conducted a prospective, open, non-comparative multicentre study in two Australian academic medical centres. Ten men with gonadotrophin deficiency requiring induction of spermatogenesis and fertility were treated with HCG for 3-6 months followed by the s.c. self-administration of injections of r-hFSH in combination with HCG for 18 months. Among the eight men who commenced r-hFSH treatment, seven demonstrated sperm output at a median of 6 months and five achieved the target sperm output of 1. 5x10(6) per ml at a median of 9 months of FSH treatment. Mean testicular volume increased by 4.2 ml during FSH treatment. Three men produced pregnancies in their partners, two of which resulted in the birth of healthy babies and a third patient's partner had a miscarriage. We conclude that r-hFSH is well tolerated and effective in inducing testis growth, spermatogenesis and fertility in gonadotrophin-deficient men. The efficacy of r-hFSH seems comparable with urinary FSH at restoring normal fertility in gonadotrophin-deficient men. |
| Databáze: | OpenAIRE |
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