Peculiarities of Pharmacokinetics and Bioavailability of Some Cardiovascular Drugs under Conditions of Antiorthostatic Hypokinesia
| Autor: | I. V. Kovachevich, Andrey A. Svistunov, A. V. Polyakov, S. N. Kondratenko, Marina I Savelyeva, Kukes Vg, L. G. Repenkova |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male 0301 basic medicine medicine.medical_specialty Biological Availability Hypokinesia Propranolol General Biochemistry Genetics and Molecular Biology 03 medical and health sciences 0302 clinical medicine Pharmacokinetics Phenothiazines Oral administration Internal medicine medicine Humans Weightlessness Simulation Volume of distribution Ethacizine Chemistry Cardiovascular Agents General Medicine Middle Aged Bioavailability 030104 developmental biology Endocrinology Verapamil Area Under Curve medicine.symptom 030217 neurology & neurosurgery Half-Life medicine.drug |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 168:465-469 |
| ISSN: | 1573-8221 0007-4888 |
| DOI: | 10.1007/s10517-020-04732-w |
| Popis: | We studied pharmacokinetics and bioavailability of verapamil, propranolol, and ethacizine in healthy volunteers after single oral administration under normal conditions and on the second day of simulated antiorthostatic hypokinesia modeling some effects of microgravity. Under conditions of antiorthostatic hypokinesia, a tendency to a decrease in half-elimination period, mean retention time, and volume of distribution and an increase in the rate of absorption, ratio of maximum concentrations, and relative rate of absorption of verapamil and propranolol were revealed. For ethacizine, a statistically significant increase in the time of attaining maximum concentration and volume of distribution and a decrease in the maximum concentration, rate of absorption, ratio of maximum concentrations, and relative rate of absorption under conditions of antiorthostatic hypokinesia were found. |
| Databáze: | OpenAIRE |
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