Breaking the Convention: Sialoglycan Variants, Coreceptors, and Alternative Receptors for Influenza A Virus Entry

Autor:	Marie O. Pohl, Silke Stertz, Umut Karakus
Přispěvatelé:	University of Zurich, Stertz, Silke
Rok vydání:	2020
Předmět:	10028 Institute of Medical Virology 1109 Insect Science media_common.quotation_subject Immunology Neuraminidase Virus Attachment Hemagglutinin (influenza) Hemagglutinin Glycoproteins Influenza Virus 610 Medicine & health Sialic acid binding Biology medicine.disease_cause Major histocompatibility complex Microbiology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Viral entry Chiroptera Virology Influenza A virus medicine Animals Humans Receptor Internalization 030304 developmental biology media_common 2403 Immunology 0303 health sciences Gem 2404 Microbiology Histocompatibility Antigens Class II Virus Internalization N-Acetylneuraminic Acid Sialic acid HEK293 Cells chemistry Insect Science 2406 Virology biology.protein Receptors Virus 570 Life sciences biology 030217 neurology & neurosurgery
Zdroj:	J Virol
ISSN:	1098-5514 0022-538X
Popis:	The influenza A virus (IAV) envelope protein hemagglutinin binds α2,6- or α2,3-linked sialic acid as a host cell receptor. Bat IAV subtypes H17N10 and H18N11 form an exception to this rule and do not bind sialic acid but enter cells via major histocompatibility complex (MHC) class II. Here, we review current knowledge on IAV receptors with a focus on sialoglycan variants, protein coreceptors, and alternative receptors that impact IAV attachment and internalization beyond the well-described sialic acid binding.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10bef747b22fb7bcbf92523589b1b07c https://doi.org/10.1128/jvi.01357-19 Zobrazit plný text záznamu