The Association between Marine n-3 Polyunsaturated Fatty Acid Levels and Survival after Renal Transplantation
| Autor: | Kristian S. Bjerve, My Svensson, Lien M. Diep, Anders Hartmann, Jeppe Hagstrup Christensen, Ivar Eide, Erik Berg Schmidt, Trond Jenssen, Anna Varberg Reisæter, Dag Olav Dahle |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Adult
Male Chromatography Gas Time Factors Adolescent Epidemiology Phospholipid Physiology Kaplan-Meier Estimate Critical Care and Intensive Care Medicine Cohort Studies chemistry.chemical_compound Young Adult Risk Factors Cause of Death Fatty Acids Omega-3 Medicine Animals Humans Registries Kidney transplantation Cause of death Aged Proportional Hazards Models chemistry.chemical_classification Aged 80 and over Transplantation business.industry Proportional hazards model Norway Mortality rate Fishes Original Articles Middle Aged Protective Factors medicine.disease Kidney Transplantation Treatment Outcome chemistry Seafood Nephrology Multivariate Analysis Linear Models Female business Cohort study Polyunsaturated fatty acid |
| Zdroj: | Eide, I A, Jenssen, T, Hartmann, A, Diep, L M, Dahle, D O, Reisæter, A V, Bjerve, K S, Christensen, J H, Schmidt, E B & Svensson, M 2015, ' The Association between Marine n-3 Polyunsaturated Fatty Acid Levels and Survival after Renal Transplantation ', Clinical Journal of American Society of Nephrology., vol. 10, no. 7, pp. 1246-1256 . https://doi.org/10.2215/CJN.11931214 |
| DOI: | 10.2215/CJN.11931214 |
| Popis: | BACKGROUND AND OBJECTIVES: Several studies have reported beneficial cardiovascular effects of marine n-3 polyunsaturated fatty acids. To date, no large studies have investigated the potential benefits of marine n-3 polyunsaturated fatty acids in recipients of renal transplants.DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: In this observational cohort study of 1990 Norwegian recipients of renal transplants transplanted between 1999 and 2011, associations between marine n-3 polyunsaturated fatty acid levels and mortality were investigated by stratified analysis and multivariable Cox proportional hazard regression analysis adjusting for traditional and transplant-specific mortality risk factors. Marine n-3 polyunsaturated fatty acid levels in plasma phospholipids were measured by gas chromatography in a stable phase 10 weeks after transplantation.RESULTS: There were 406 deaths (20.4%) during a median follow-up period of 6.8 years. Mortality rates were lower in patients with high marine n-3 polyunsaturated fatty acid levels (≥7.95 weight percentage) compared with low levels (CONCLUSIONS: Higher plasma phospholipid marine n-3 polyunsaturated fatty acid levels were independently associated with better patient survival. |
| Databáze: | OpenAIRE |
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