Genome-wide analysis of abdominal and pleural malignant mesothelioma with DNA arrays reveals both common and distinct regions of copy number alteration
| Autor: | Jianming Pei, Brynn Levy, Jinli Chen, Joseph R. Testa, Odelia Nahum, Alain C. Borczuk, Robert N. Taub, Katherine Chen |
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| Rok vydání: | 2016 |
| Předmět: |
Mesothelioma
0301 basic medicine Cancer Research Pathology medicine.medical_specialty Lung Neoplasms DNA Copy Number Variations Pleural Neoplasms Biology 03 medical and health sciences Peritoneal Neoplasm Pleural disease 0302 clinical medicine CDKN2A medicine Humans Pleural Neoplasm Peritoneal Neoplasms Pharmacology BAP1 Mesothelioma Malignant medicine.disease 030104 developmental biology Oncology Abdominal Neoplasms 030220 oncology & carcinogenesis Mutation Peritoneal mesothelioma Molecular Medicine Sarcoma Genome-Wide Association Study Research Paper |
| Zdroj: | Cancer Biology & Therapy. 17:328-335 |
| ISSN: | 1555-8576 1538-4047 |
| DOI: | 10.1080/15384047.2016.1145850 |
| Popis: | Malignant mesothelioma (MM) is an aggressive tumor arising from mesothelial linings of the serosal cavities. Pleural space is the most common site, accounting for about 80% of cases, while peritoneum makes up the majority of the remaining 20%. While histologically similar, tumors from these sites are epidemiologically and clinically distinct and their attribution to asbestos exposure differs. We compared DNA array-based findings from 48 epithelioid peritoneal MMs and 41 epithelioid pleural MMs to identify similarities and differences in copy number alterations (CNAs). Losses in 3p (BAP1 gene), 9p (CDKN2A) and 22q (NF2) were seen in tumors from both tumor sites, although CDKN2A and NF2 losses were seen at a higher rate in pleural disease (p |
| Databáze: | OpenAIRE |
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