Axonal transport of the voltage-dependent Na+ channel protein identified by its tetrodotoxin binding site in rat sciatic nerves
| Autor: | Christiane Mourre, Pierre M. Laduron, Yves Jacomet, Michel Lazdunski, Alain Lombet |
|---|---|
| Rok vydání: | 1985 |
| Předmět: |
Male
Fast axoplasmic transport medicine.medical_treatment Nerve Tissue Proteins Tetrodotoxin In Vitro Techniques Axonal Transport Sodium Channels chemistry.chemical_compound medicine Animals Peripheral Nerves Binding site Ligature Molecular Biology Binding Sites musculoskeletal neural and ocular physiology General Neuroscience Sodium Retrograde axoplasmic transport Membrane Proteins Rats Inbred Strains Anatomy In vitro binding Rats nervous system chemistry Axoplasmic transport Biophysics Neurology (clinical) Sciatic nerve Developmental Biology |
| Zdroj: | Brain Research. 345:153-158 |
| ISSN: | 0006-8993 |
| DOI: | 10.1016/0006-8993(85)90846-7 |
| Popis: | Na+ channels levels were measured in different segments of rat vagus and sciatic nerves by in vitro binding using a tritiated ethylenediamine tetrodotoxin derivative ([3H]en-TTX). Binding sites were found to accumulate on both sides of a ligature tied on the sciatic nerve indicating an anterograde and retrograde axoplasmic transport of Na+ channels. Accumulation of Na+ channels at the ligature was time-dependent and appeared to occur through fast axoplasmic transport mechanisms. This accumulation on both sides of a ligature was also visualized by autoradiographic studies in longitudinal sections of sciatic nerves using [3H]en-TTX. |
| Databáze: | OpenAIRE |
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