Relationship between blood lipid and arterial stiffness in hypertension
| Autor: | Wei Liu, Xiao-Bei Si |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty Mean arterial pressure Blood lipids Blood Pressure 02 engineering and technology Coronary Artery Disease 01 natural sciences Body Mass Index 010309 optics Vascular Stiffness Heart Rate Internal medicine Diabetes mellitus 0103 physical sciences 0202 electrical engineering electronic engineering information engineering medicine Diabetes Mellitus Humans Pulse wave velocity Aged Dyslipidemias Retrospective Studies business.industry 020208 electrical & electronic engineering Age Factors nutritional and metabolic diseases General Medicine Middle Aged medicine.disease Lipids Pulse pressure Blood pressure Hypertension Cardiology Arterial stiffness Female business Dyslipidemia |
| Zdroj: | Clinical and investigative medicine. Medecine clinique et experimentale. 42(3) |
| ISSN: | 1488-2353 |
| Popis: | Purpose: To explore the relationship between blood lipids and pulse wave velocity (PWV). Methods: We retrospectively selected subjects who had undergone treatment in an outpatient or inpatient clinic. The subjects were sub-grouped into four groups: Group A (no history of hypertension and dyslipidemia), Group B (a history of dyslipidemia but not hypertension), Group C (a history of hypertension but not dyslipidemia) and Group D (a history of both hypertension and dyslipidemia). We determined brachial-ankle pulse wave velocity (baPWV), atherogenic index of plasma (AIP), non-high-density lipoprotein (non-HDL-C), total cholesterol/high density lipoprotein (TC/HDL-C) and atherogenic indices (AI) for hypertension and non-hypertension and dyslipidemia and non-dyslipidemia patients. Results: A total of 380 subjects were included. Uric acid, systolic pressure, diastolic pressure, pulse pressure and mean arterial pressure were significantly different among the groups. The prevalence of coronary arterial disease and diabetes mellitus, age, body mass index, heart rate, blood glucose, creatinine, urea, smoking history and alcohol consumption did not differ among groups. The baPWV was significantly different between both hypertension/nonhypertension and dyslipidemia/non-dyslipidemia patients. In hypertension patients (in Group C and D), partial correlation analysis showed that ΔbaPWV correlated with TC, HDL-C, AI, AIP and TC/HDL-C but not LDL-C, triglyceride (TG) or non-HDL-C. Conclusion: Hypertension and/or dyslipidemia may be risk factors for arterial stiffness. In hypertension patients, TC, HDL-C, AIP, AI and TC/HDL-C might correlate to arterial stiffness and pathological increases in these levels may indicate risk factors for arterial stiffness. |
| Databáze: | OpenAIRE |
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