Pulmonary embolism attenuation is a potential imaging biomarker for pulmonary artery hemodynamic improvement after catheter-directed thrombolysis
| Autor: | Courtney N. Day, Melissa J. Neisen, William S. Harmsen, Newton B. Neidert, Christopher J. Reisenauer, Haraldur Bjarnason, Andrew H. Stockland, Edwin A. Takahashi, Sanjay Misra |
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| Rok vydání: | 2018 |
| Předmět: |
Male
medicine.medical_specialty Computed Tomography Angiography Mechanical Thrombolysis Haemodynamic response medicine.medical_treatment Hemodynamics Pulmonary Artery 030204 cardiovascular system & hematology 03 medical and health sciences 0302 clinical medicine Fibrinolytic Agents Internal medicine medicine.artery medicine Pulmonary angiography Humans Thrombolytic Therapy Retrospective Studies business.industry Thrombolysis Middle Aged medicine.disease Pulmonary embolism Treatment Outcome medicine.anatomical_structure Ventricle Pulmonary artery Cardiology Ventricular pressure Female Pulmonary Embolism Cardiology and Cardiovascular Medicine business Biomarkers 030217 neurology & neurosurgery |
| Zdroj: | Vascular Medicine. 23:134-138 |
| ISSN: | 1477-0377 1358-863X |
| Popis: | This study examined the potential correlation between pulmonary embolism (PE) attenuation on computed tomography pulmonary angiography (CTPA) and pulmonary artery hemodynamic response to catheter-directed thrombolysis (CDT) in 10 patients with submassive PE. Treatment parameters, PE attenuation, clot burden, computed tomography signs of right ventricle dysfunction and right ventricular systolic pressure at echocardiography were retrospectively analyzed to determine correlation with pulmonary artery pressure improvement using Spearman correlation. A single reader, blinded to the treatment results, measured PE attenuation of all patients. There was a significant positive correlation between PE attenuation and absolute pulmonary artery pressure improvement with a Spearman correlation of 0.741, p=0.014. When attenuation was greater than or equal to the median (44.5 HU, n=5), CDT was associated with significantly better pulmonary artery pressure improvement ( p=0.037). Clot attenuation at CTPA may be a potential imaging biomarker for predicting pulmonary artery pressure improvement after CDT. |
| Databáze: | OpenAIRE |
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