Jacob-induced transcriptional inactivation of CREB promotes Aβ-induced synapse loss in Alzheimer's disease
| Autor: | Katarzyna M Grochowska, Guilherme M Gomes, Rajeev Raman, Rahul Kaushik, Liudmila Sosulina, Hiroshi Kaneko, Anja M Oelschlegel, PingAn Yuanxiang, Irene Reyes‐Resina, Gonca Bayraktar, Sebastian Samer, Christina Spilker, Marcel S Woo, Markus Morawski, Jürgen Goldschmidt, Manuel A Friese, Steffen Rossner, Gemma Navarro, Stefan Remy, Carsten Reissner, Anna Karpova, Michael R Kreutz |
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| Jazyk: | angličtina |
| Rok vydání: | 2023 |
| Předmět: |
General Immunology and Microbiology
CREB General Neuroscience early synaptic dysfunction metabolism [Amyloid beta-Peptides] genetics [Alzheimer Disease] Mice Transgenic Jacob Amyloid pathology Alzheimer's disease metabolism [Synapses] General Biochemistry Genetics and Molecular Biology Mice metabolism [Neurons] ddc:570 Animals Molecular Biology metabolism [Alzheimer Disease] |
| Zdroj: | The EMBO journal, 42(4):e112453 The EMBO journal 42(4), e112453 (2023). doi:10.15252/embj.2022112453 |
| Popis: | Synaptic dysfunction caused by soluble β-amyloid peptide (Aβ) is a hallmark of early-stage Alzheimer's disease (AD), and is tightly linked to cognitive decline. By yet unknown mechanisms, Aβ suppresses the transcriptional activity of cAMP-responsive element-binding protein (CREB), a master regulator of cell survival and plasticity-related gene expression. Here, we report that Aβ elicits nucleocytoplasmic trafficking of Jacob, a protein that connects a NMDA-receptor-derived signalosome to CREB, in AD patient brains and mouse hippocampal neurons. Aβ-regulated trafficking of Jacob induces transcriptional inactivation of CREB leading to impairment and loss of synapses in mouse models of AD. The small chemical compound Nitarsone selectively hinders the assembly of a Jacob/LIM-only 4 (LMO4)/ Protein phosphatase 1 (PP1) signalosome and thereby restores CREB transcriptional activity. Nitarsone prevents impairment of synaptic plasticity as well as cognitive decline in mouse models of AD. Collectively, the data suggest targeting Jacob protein-induced CREB shutoff as a therapeutic avenue against early synaptic dysfunction in AD. |
| Databáze: | OpenAIRE |
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