A Promising Novel Therapy for Achilles Peritendinitis:Double-Blind Comparison of Glycosaminoglycan Polysulfate and High-Dose Indomethacin
| Autor: | B. Forsskåhl, M. Kvist, H. Sundqvist |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.medical_treatment Indomethacin Administration Oral Physical Therapy Sports Therapy and Rehabilitation Achilles Tendon Injections Intramuscular law.invention Random Allocation Pharmacotherapy Double-Blind Method Tendinitis Randomized controlled trial law Oral administration medicine Humans Orthopedics and Sports Medicine Glycosaminoglycans Clinical Trials as Topic Chemotherapy Achilles tendon business.industry Therapeutic effect Middle Aged medicine.disease Orthotic device Surgery medicine.anatomical_structure Anesthesia Tendinopathy business |
| Zdroj: | International Journal of Sports Medicine. :298-303 |
| ISSN: | 1439-3964 0172-4622 |
| DOI: | 10.1055/s-2008-1025673 |
| Popis: | In this double-blind trial in 60 recreational athletes suffering from Achilles peritendinitis, we compared the effect of local injections of glycosaminoglycan polysulfate (GAGPS) with oral indomethacin (IM) administered over a 2-week period. Orthotic devices were prescribed in 66% of the cases to control biomechanical errors. The results after 1-year follow-up showed that GAGPS had a good overall therapeutic effect on two-thirds of the patients compared to one-third of the IM treated. In the patients with symptoms lasting longer than 3 months, IM had an effect in only 12% while GAGPS was beneficial in 59%. Twenty-five cases of non-responders and relapses underwent a crossover treatment. Those who received IM in this second period did not benefit from this treatment while those who received GAGPS showed a moderate to good effect in 8/17 (47%) after a 2-week follow-up. A different mode of action is suggested as an explanation of the encouraging results. |
| Databáze: | OpenAIRE |
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