Population size impacts host-pathogen coevolution
Autor: | Andrei Papkou, Rebecca Schalkowski, Mike-Christoph Barg, Svenja Koepper, Hinrich Schulenburg |
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Přispěvatelé: | University of Zurich |
Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
population size
host–pathogen coevolution Evolution Bacillus thuringiensis Genetics and Molecular Biology 1100 General Agricultural and Biological Sciences General Biochemistry Genetics and Molecular Biology Host-Parasite Interactions 2300 General Environmental Science 10127 Institute of Evolutionary Biology and Environmental Studies 1300 General Biochemistry Genetics and Molecular Biology 2400 General Immunology and Microbiology population bottleneck red queen dynamics Research Articles General Environmental Science Population Density General Immunology and Microbiology Genetic Drift General Medicine Biological Evolution Host-Pathogen Interactions General Biochemistry 570 Life sciences biology 590 Animals (Zoology) General Agricultural and Biological Sciences |
Zdroj: | Proceedings of the Royal Society B: Biological Sciences |
Popis: | Ongoing host–pathogen interactions are characterized by rapid coevolutionary changes forcing species to continuously adapt to each other. The interacting species are often defined by finite population sizes. In theory, finite population size limits genetic diversity and compromises the efficiency of selection owing to genetic drift, in turn constraining any rapid coevolutionary responses. To date, however, experimental evidence for such constraints is scarce. The aim of our study was to assess to what extent population size influences the dynamics of host–pathogen coevolution. We usedCaenorhabditus elegansand its pathogenBacillus thuringiensisas a model for experimental coevolution in small and large host populations, as well as in host populations which were periodically forced through a bottleneck. By carefully controlling host population size for 23 host generations, we found that host adaptation was constrained in small populations and to a lesser extent in the bottlenecked populations. As a result, coevolution in large and small populations gave rise to different selection dynamics and produced different patterns of host–pathogen genotype-by-genotype interactions. Our results demonstrate a major influence of host population size on the ability of the antagonists to co-adapt to each other, thereby shaping the dynamics of antagonistic coevolution. |
Databáze: | OpenAIRE |
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