Effect of morphine on lipopolysaccharide-induced tumor necrosis factor-alpha production in vivo: involvement of the sympathetic nervous system
| Autor: | Agnes Bencsics, Ilia J. Elenkov, E. Sylvester Vizi |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Lipopolysaccharides
Male Narcotics medicine.medical_specialty Sympathetic nervous system Sympathetic Nervous System Time Factors Narcotic Antagonists Immunology (+)-Naloxone Chlorisondamine Subcutaneous injection chemistry.chemical_compound Mice In vivo Internal medicine medicine Immunology and Allergy Animals Dose-Response Relationship Drug Morphine business.industry Naloxone Tumor Necrosis Factor-alpha Endocrinology medicine.anatomical_structure Neurology Opioid chemistry Receptors Opioid Tumor necrosis factor alpha Neurology (clinical) business medicine.drug |
| Zdroj: | Journal of neuroimmunology. 73(1-2) |
| ISSN: | 0165-5728 |
| Popis: | Morphine treatment modulates a variety of immunological parameters, including tumor necrosis factor-alpha (TNF-alpha) production by activated macrophages in vitro. The aim of our study was to clarify the effect of morphine on lipopolysaccharide (LPS)-induced TNF-alpha production in vivo. Plasma TNF-alpha levels of mice were determined by ELISA. Subcutaneous injection of morphine decreased LPS-induced TNF-alpha production throughout the response, an effect that was dose-dependent and reversible by naloxone. Blockade of the sympathetic transmission by chlorisondamine prevented the inhibitory effect of morphine on TNF-alpha production. It is concluded that (i) systemic administration of morphine inhibits LPS-induced TNF-alpha production in vivo via 'classic' opioid receptors; (ii) this effect requires intact sympathetic outflow. Since the increased incidence of bacterial and viral infections in opioid addicts is well documented, it is suggested that the inhibitory effect of morphine on TNF-alpha production might play a substantial role in the increased vulnerability of these individuals to certain infections. |
| Databáze: | OpenAIRE |
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