Synergistic interaction between acetaminophen and L-carnosine improved neuropathic pain via NF-κB pathway and antioxidant properties in chronic constriction injury model
| Autor: | Bamidele Victor Owoyele, Ahmed Olalekan Bakare, Olutayo Folajimi Olaseinde, Mohammed Jelil Ochu, Akorede Munirdeen Yusuff, Favour Ekebafe, Oluwadamilare Lanre Fogabi, Treister Roi |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | The Korean Journal of Pain. 35:271-279 |
| ISSN: | 2093-0569 2005-9159 |
| Popis: | Inflammation is known to underlie the pathogenesis in neuropathic pain. This study investigated the anti-inflammatory and neuroprotective mechanisms involved in antinociceptive effects of co-administration of acetaminophen and L-carnosine in chronic constriction injury (CCI)-induced peripheral neuropathy in male Wistar rats.Fifty-six male Wistar rats were randomly divided into seven experimental groups (n = 8) treated with normal saline/acetaminophen/acetaminophen + L-carnosine. CCI was used to induce neuropathic pain in rats. Hyperalgesia and allodynia were assessed using hotplate and von Frey tests, respectively. Investigation of spinal proinflammatory cytokines and antioxidant system were carried out after twenty-one days of treatment.The results showed that the co-administration of acetaminophen and L-carnosine significantly (Co-administration of acetaminophen and L-carnosine has anti-inflammatory effects as a mechanism that mediate its antinociceptive effects in CCI-induced peripheral neuropathy in Wistar rat. |
| Databáze: | OpenAIRE |
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