The Bewildering Antitubercular Action of Pyrazinamide
Autor: | Anthony D. Baughn, Nicholas Dillon, Elise A. Lamont |
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Rok vydání: | 2020 |
Předmět: |
Drug
medicine.medical_specialty Tuberculosis media_common.quotation_subject Antitubercular Agents Review Drug resistance Biology Microbiology Mice 03 medical and health sciences Pharmacotherapy Drug Development Drug Resistance Multiple Bacterial Tuberculosis Multidrug-Resistant medicine Animals Humans Intensive care medicine Mode of action Molecular Biology 030304 developmental biology media_common Clinical Trials as Topic 0303 health sciences 030306 microbiology Mycobacterium tuberculosis Pyrazinamide medicine.disease Infectious Diseases Drug development Action (philosophy) Mutation medicine.drug |
Zdroj: | Microbiol Mol Biol Rev |
ISSN: | 1098-5557 1092-2172 |
Popis: | SUMMARY Pyrazinamide (PZA) is a cornerstone antimicrobial drug used exclusively for the treatment of tuberculosis (TB). Due to its ability to shorten drug therapy by 3 months and reduce disease relapse rates, PZA is considered an irreplaceable component of standard first-line short-course therapy for drug-susceptible TB and second-line treatment regimens for multidrug-resistant TB. Despite over 60 years of research on PZA and its crucial role in current and future TB treatment regimens, the mode of action of this unique drug remains unclear. Defining the mode of action for PZA will open new avenues for rational design of novel therapeutic approaches for the treatment of TB. In this review, we discuss the four prevailing models for PZA action, recent developments in modulation of PZA susceptibility and resistance, and outlooks for future research and drug development. |
Databáze: | OpenAIRE |
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