Pulmonary hypertension registry of Kerala, India (PRO-KERALA) - Clinical characteristics and practice patterns
| Autor: | Thankachan V. Attacheril, Raman Krishna Kumar, S.M. Ashraf, A. George Koshy, Gopalan Nair Rajesh, S.R. Arun, G. Sanjay, Sivadasanpillai Harikrishnan, Raju George, Eapen Punnoose, Mohammed Cholakkal, M. Ashishkumar, Jaideep Menon, Panniyammakal Jeemon |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male medicine.medical_specialty Heart disease Idiopathic Pulmonary Hypertension Hypertension Pulmonary Population India 030204 cardiovascular system & hematology Coronary artery disease 03 medical and health sciences 0302 clinical medicine Internal medicine medicine.artery Epidemiology medicine Humans Registries education Aged education.field_of_study business.industry Middle Aged medicine.disease Pulmonary hypertension 030228 respiratory system Pulmonary artery Population study Female Cardiology and Cardiovascular Medicine business Follow-Up Studies |
| Zdroj: | International journal of cardiology. 265 |
| ISSN: | 1874-1754 |
| Popis: | Background Epidemiological data on pulmonary hypertension (PH) are scarce from developing countries including India. Methods We established a multi-center registry of PH, the PRO-KERALA registry, in Kerala, India. Fifty hospitals enrolled consecutive adult (>18 years) patients for one year. Echocardiographic criteria (right ventricular systolic pressure – RVSP > 50 mmHg) or invasively obtained mean pulmonary artery pressure > 25 mmHg was the criteria for entry. Results There were 2003 patients (52% Women, mean age 56 ± 16.1 years) enrolled. The mean RVSP was 68.2 (SD = 17.9) mmHg. Majority of the study participants (59%) belonged to group 2 of the WHO Nice Classification 2013 (PH secondary to left heart disease). One-fifth (21.2%) belonged to group 1, while 13.3%, 3.8% and 2.4% of the study population belonged to groups 3, 4 and 5 respectively. More than a quarter (27%) reported PH due to left heart disease with valvular disease etiology; while 20.7% had coronary artery disease. The other common etiological factors were chronic obstructive pulmonary disease (10.6%), congenital heart disease (14.6%), idiopathic pulmonary hypertension (5.8%), and chronic thromboembolic pulmonary hypertension (3.8%). Only one of two patients with pulmonary artery hypertension was receiving PH specific therapies. The use of combination therapy was negligible and PH-specific therapies were prescribed off-label to a small proportion of patients too. Conclusion PRO-KERALA is the first PH registry from South Asia and the second largest globally. Left heart diseases attribute to three fifths of patients with PH. Utilization rates of PH specific drug therapies are remarkably lower than the Western population. |
| Databáze: | OpenAIRE |
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