Cyclin D1 Triggers Autonomous Growth of Breast Cancer Cells by Governing Cell Cycle Exit
| Autor: | Ellen Wientjens, P. M. P. Kristel, Rob Michalides, B. Van Der Burg, Rob Klompmaker, Renate M. L. Zwijsen |
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| Rok vydání: | 1996 |
| Předmět: |
Transcriptional Activation
Cyclin E Cyclin D Cyclin A Cyclin B Gene Expression Breast Neoplasms Transfection Retinoblastoma Protein Cyclin D1 Cyclins Tumor Cells Cultured Humans Phosphorylation Molecular Biology Cyclin Oncogene Proteins biology Cell Cycle Cell Biology Tetracycline Cell cycle Culture Media Cell biology Kinetics biology.protein Cancer research Female Cell Division Cyclin A2 Research Article |
| Zdroj: | Molecular and Cellular Biology. 16:2554-2560 |
| ISSN: | 1098-5549 |
| DOI: | 10.1128/mcb.16.6.2554 |
| Popis: | Cyclin D1 controls G1-associated processes, including G0-to-G1 and G1-to-S transitions. This study demonstrates a novel aspect of cyclin D1 as a regulator of the transition between G1 and G0. Overexpression of cyclin D1 in MCF7 breast tumor cells resulted in a continued proliferation under low-serum conditions, whereas nonoverexpressing cells ceased to grow. This difference in growth was due to a reduced exit from G1 to G0 in cyclin D1-overexpressing cells. Our data therefore suggest a model in which cyclin D1 overexpression in tumor cells is responsible for hyperproliferation under growth factor-deprived conditions. |
| Databáze: | OpenAIRE |
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